Rapid Vessel Regression, Protease Inhibition, and Stromal Normalization upon Short-Term Vascular Endothelial Growth Factor Receptor 2 Inhibition in Skin Carcinoma Heterotransplants

Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis, and blockade of VEGF receptor 2 (VEGFR-2), with the monoclonal antibody DC101, inhibits angiogenesis and tumor growth. To examine the short-term effects of DC101, we surface transplanted the squamous cell carcinoma cel...

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Veröffentlicht in:	The American journal of pathology 2005-11, Vol.167 (5), p.1389-1403
Hauptverfasser:	Miller, Daniel W., Vosseler, Silvia, Mirancea, Nicolae, Hicklin, Daniel J., Bohlen, Peter, Völcker, Hans E., Holz, Frank G., Fusenig, Norbert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Basement Membrane - ultrastructure Biological and medical sciences Blood Vessels - pathology Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Proliferation Collagenases - metabolism Endothelial Cells - cytology Endothelium, Vascular - pathology Gelatinases - metabolism Humans In Situ Hybridization Investigative techniques, diagnostic techniques (general aspects) Matrix Metalloproteinase 13 Matrix Metalloproteinase 9 - metabolism Medical sciences Mice Mice, Nude Microscopy, Electron, Transmission Microscopy, Fluorescence Neoplasm Transplantation Original Research Paper Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Skin Neoplasms - blood supply Skin Neoplasms - enzymology Skin Neoplasms - pathology Transplantation, Heterologous Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - immunology
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