Expression of Tight-Junction Protein Claudin-7 Is an Early Event in Gastric Tumorigenesis

Trefoil factor-1 (Tff1) expression is remarkably down-regulated in nearly all human gastric cancers. Therefore, we used the Tff1 knockout mouse model to detect molecular changes in preneoplastic gastric dysplasia. Oligonucleotide microarray gene expression analysis of gastric dysplasia of Tff1 −/− m...

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Veröffentlicht in:	The American journal of pathology 2005-08, Vol.167 (2), p.577-584
Hauptverfasser:	Johnson, Adam H., Frierson, Henry F., Zaika, Alexander, Powell, Steven M., Roche, James, Crowe, Sheila, Moskaluk, Christopher A., El-Rifai, Wa'el
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Aged Aged, 80 and over Animals Biological and medical sciences Claudins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early Growth Response Protein 1 Estrogens - metabolism Female Gastric Mucosa - metabolism Gastric Mucosa - pathology Gene Expression Profiling Growth Inhibitors - metabolism Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Metaplasia - genetics Metaplasia - metabolism Metaplasia - pathology Mice Mice, Knockout Middle Aged Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oligonucleotide Array Sequence Analysis Original Research Paper Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tight Junctions Transcription Factors - genetics Transcription Factors - metabolism Trefoil Factor-1 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology
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