Contribution of Transmembrane Tumor Necrosis Factor to Host Defense against Mycobacterium bovis Bacillus Calmette-Guerin and Mycobacterium tuberculosis Infections

To study the specific role of transmembrane tumor necrosis factor (TmTNF) in host defense mechanisms against bacillus Calmette-Guerin (BCG) and Mycobacterium tuberculosis infections, we compared the immune responses of TNF/lymphotoxin (LT)-α −/− mice expressing a noncleavable transgenic TmTNF (TmTNF...

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Veröffentlicht in:	The American journal of pathology 2005-04, Vol.166 (4), p.1109-1120
Hauptverfasser:	Olleros, Maria L., Guler, Reto, Vesin, Dominique, Parapanov, Roumen, Marchal, Gilles, Martinez-Soria, Eduardo, Corazza, Nadia, Pache, Jean-Claude, Mueller, Christoph, Garcia, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Chemokine CCL2 - metabolism Chemokine CCL5 - metabolism Cytokines - metabolism Flow Cytometry Granuloma - immunology Immunohistochemistry In Situ Hybridization Investigative techniques, diagnostic techniques (general aspects) Lung - cytology Lung - immunology Lung - pathology Lymphotoxin-alpha - genetics Lymphotoxin-alpha - immunology Medical sciences Mice Mice, Transgenic Mycobacterium bovis - immunology Nitric Oxide Synthase - immunology Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Original Research Paper Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Spleen - cytology Spleen - immunology Tuberculosis - immunology Tuberculosis - pathology Tuberculosis - veterinary Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
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