Genetic Difference in Susceptibility to the Blood-Retina Barrier Breakdown in Diabetes and Oxygen-Induced Retinopathy

The breakdown of the blood-retina barrier (BRB) is a common feature of diabetic retinopathy. The purpose of the present study is to determine whether there are genetic differences in susceptibility to the breakdown of the BRB in diabetic retinopathy using two rat models. In streptozotocin (STZ)-indu...

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Veröffentlicht in:	The American journal of pathology 2005, Vol.166 (1), p.313-321
Hauptverfasser:	Zhang, Sarah X., Ma, Jian-xing, Sima, Jing, Chen, Ying, Hu, Mark S., Ottlecz, Anna, Lambrou, George N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular System - pathology Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Diabetic Retinopathy - chemically induced Diabetic Retinopathy - pathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Insulin-Like Growth Factor I - pharmacology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Original Research Paper Oxygen - toxicity Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Permeability Rats Rats, Inbred BN Rats, Sprague-Dawley Retina - drug effects Retina - pathology Retinal Vessels - drug effects Retinal Vessels - pathology Vascular Endothelial Growth Factor A - pharmacology
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