Brain and Bone Damage in KARAP/DAP12 Loss-of-Function Mice Correlate with Alterations in Microglia and Osteoclast Lineages

Human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy, also known as Nasu-Hakola disease, has been described to be associated with mutations affecting the immunoreceptor tyrosine-based activation motif-bearing KARAP/DAP12 immunoreceptor gene. Patients present bone fragi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology 2005, Vol.166 (1), p.275-286
Hauptverfasser:	Nataf, Serge, Anginot, Adrienne, Vuaillat, Carine, Malaval, Luc, Fodil, Nassima, Chereul, Emmanuel, Langlois, Jean-Baptiste, Dumontel, Christiane, Cavillon, Gaelle, Confavreux, Christian, Mazzorana, Marlène, Vico, Laurence, Belin, Marie-Franaçoise, Vivier, Eric, Tomasello, Elena, Jurdic, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Animals Biological and medical sciences Bone Diseases Bone Diseases - genetics Bone Diseases - pathology Brain Damage, Chronic Brain Damage, Chronic - genetics Brain Damage, Chronic - pathology Immunology Investigative techniques, diagnostic techniques (general aspects) Life Sciences Medical sciences Mice Mice, Knockout Microglia Microglia - pathology Original Research Paper Osteoclasts Osteoclasts - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Immunologic Receptors, Immunologic - deficiency Receptors, Immunologic - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!