Inhibition of p38 Mitogen-Activated Protein Kinase Augments Progression of Remnant Kidney Model by Activating the ERK Pathway

p38, a mitogen-activated protein kinase, is a major intracellular signaling molecule involved in inflammation. To test the hypothesis that p38 mediates renal disease progression, we administered a novel p38α inhibitor, NPC31169, to rats with remnant kidneys (RKs). RK rats showed increased p38 activa...

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Veröffentlicht in:	The American journal of pathology 2004-02, Vol.164 (2), p.477-485
Hauptverfasser:	Ohashi, Ryuji, Nakagawa, Takahiko, Watanabe, Susumu, Kanellis, John, Almirez, Ramona G., Schreiner, George F., Johnson, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Blotting, Western Disease Models, Animal Enzyme Activation - physiology Enzyme Inhibitors - therapeutic use Immunohistochemistry In Situ Nick-End Labeling Investigative techniques, diagnostic techniques (general aspects) Kidney Diseases - drug therapy Kidney Diseases - enzymology Kidney Diseases - pathology Male Medical sciences Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - physiology p38 Mitogen-Activated Protein Kinases Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphorylation Rats Rats, Sprague-Dawley Regular Signal Transduction - drug effects Signal Transduction - physiology
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