Global and depth resolved phosphorus magnetic resonance spectroscopy to predict outcome after birth asphyxia
Twelve normal and 32 asphyxiated neonates were studied using global and depth resolved phosphorus magnetic resonance spectroscopy (31PMRS). Eight of the asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below...
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| Veröffentlicht in: | Archives of disease in childhood 1991-10, Vol.66 (10 Spec No), p.1119-1123 |
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| container_issue | 10 Spec No |
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| container_title | Archives of disease in childhood |
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| creator | Moorcraft, J Bolas, N M Ives, N K Ouwerkerk, R Smyth, J Rajagopalan, B Hope, P L Radda, G K |
| description | Twelve normal and 32 asphyxiated neonates were studied using global and depth resolved phosphorus magnetic resonance spectroscopy (31PMRS). Eight of the asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below the range of values from normal infants predicted adverse outcome after asphyxia with a positive predictive value of 64%, sensitivity 88%, and specificity 83%. Corresponding values for global inorganic orthophosphate/adenosine triphosphate (Pi/ATP) ratios were positive predictive value 88%, sensitivity 96%, and specificity 88%. Spatially localised MRS data, obtained using phase modulated rotating frame imaging, showed cerebral energy metabolism to be more abnormal in deep than superficial regions after birth asphyxia. However, in this population of full term infants none of the regional metabolite concentrations were superior to global data for prediction of outcome. |
| doi_str_mv | 10.1136/adc.66.10_Spec_No.1119 |
| format | Article |
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Eight of the asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below the range of values from normal infants predicted adverse outcome after asphyxia with a positive predictive value of 64%, sensitivity 88%, and specificity 83%. Corresponding values for global inorganic orthophosphate/adenosine triphosphate (Pi/ATP) ratios were positive predictive value 88%, sensitivity 96%, and specificity 88%. Spatially localised MRS data, obtained using phase modulated rotating frame imaging, showed cerebral energy metabolism to be more abnormal in deep than superficial regions after birth asphyxia. However, in this population of full term infants none of the regional metabolite concentrations were superior to global data for prediction of outcome.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.66.10_Spec_No.1119</identifier><identifier>PMID: 1750759</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adenosine Triphosphate - metabolism ; Asphyxia ; Asphyxia Neonatorum - complications ; Asphyxia Neonatorum - metabolism ; ATP ; Biological and medical sciences ; Brain - metabolism ; Energy metabolism ; Humans ; Infant, Newborn ; Infants ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic resonance spectroscopy ; Magnetic Resonance Spectroscopy - methods ; Medical sciences ; Metabolites ; Neonates ; Neurodevelopmental disorders ; Orthophosphate ; Pediatrics ; Phosphates - metabolism ; Phosphocreatine - metabolism ; Phosphorus ; Predictive Value of Tests ; Prognosis ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Sensitivity and Specificity ; Spectroscopy</subject><ispartof>Archives of disease in childhood, 1991-10, Vol.66 (10 Spec No), p.1119-1123</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Oct 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b546t-1b0fa31c3def6140733e3cffc10be163a5396e8e87b3f66b3fe79170687fad4d3</citedby><cites>FETCH-LOGICAL-b546t-1b0fa31c3def6140733e3cffc10be163a5396e8e87b3f66b3fe79170687fad4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1590291/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1590291/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5510767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1750759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moorcraft, J</creatorcontrib><creatorcontrib>Bolas, N M</creatorcontrib><creatorcontrib>Ives, N K</creatorcontrib><creatorcontrib>Ouwerkerk, R</creatorcontrib><creatorcontrib>Smyth, J</creatorcontrib><creatorcontrib>Rajagopalan, B</creatorcontrib><creatorcontrib>Hope, P L</creatorcontrib><creatorcontrib>Radda, G K</creatorcontrib><title>Global and depth resolved phosphorus magnetic resonance spectroscopy to predict outcome after birth asphyxia</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Twelve normal and 32 asphyxiated neonates were studied using global and depth resolved phosphorus magnetic resonance spectroscopy (31PMRS). Eight of the asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below the range of values from normal infants predicted adverse outcome after asphyxia with a positive predictive value of 64%, sensitivity 88%, and specificity 83%. Corresponding values for global inorganic orthophosphate/adenosine triphosphate (Pi/ATP) ratios were positive predictive value 88%, sensitivity 96%, and specificity 88%. Spatially localised MRS data, obtained using phase modulated rotating frame imaging, showed cerebral energy metabolism to be more abnormal in deep than superficial regions after birth asphyxia. However, in this population of full term infants none of the regional metabolite concentrations were superior to global data for prediction of outcome.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Asphyxia</subject><subject>Asphyxia Neonatorum - complications</subject><subject>Asphyxia Neonatorum - metabolism</subject><subject>ATP</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Energy metabolism</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic resonance spectroscopy</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Neonates</subject><subject>Neurodevelopmental disorders</subject><subject>Orthophosphate</subject><subject>Pediatrics</subject><subject>Phosphates - metabolism</subject><subject>Phosphocreatine - metabolism</subject><subject>Phosphorus</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radiodiagnosis. 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Eight of the asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below the range of values from normal infants predicted adverse outcome after asphyxia with a positive predictive value of 64%, sensitivity 88%, and specificity 83%. Corresponding values for global inorganic orthophosphate/adenosine triphosphate (Pi/ATP) ratios were positive predictive value 88%, sensitivity 96%, and specificity 88%. Spatially localised MRS data, obtained using phase modulated rotating frame imaging, showed cerebral energy metabolism to be more abnormal in deep than superficial regions after birth asphyxia. However, in this population of full term infants none of the regional metabolite concentrations were superior to global data for prediction of outcome.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>1750759</pmid><doi>10.1136/adc.66.10_Spec_No.1119</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0003-9888 1468-2044 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphate - metabolism Asphyxia Asphyxia Neonatorum - complications Asphyxia Neonatorum - metabolism ATP Biological and medical sciences Brain - metabolism Energy metabolism Humans Infant, Newborn Infants Investigative techniques, diagnostic techniques (general aspects) Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Medical sciences Metabolites Neonates Neurodevelopmental disorders Orthophosphate Pediatrics Phosphates - metabolism Phosphocreatine - metabolism Phosphorus Predictive Value of Tests Prognosis Radiodiagnosis. Nmr imagery. Nmr spectrometry Sensitivity and Specificity Spectroscopy |
| title | Global and depth resolved phosphorus magnetic resonance spectroscopy to predict outcome after birth asphyxia |
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