Treatment of Hypothyroidism: A Reappraisal of Thyroxine Therapy
Twenty-two subjects with hypothyroidism have been studied in detail before and during replacement therapy with L-thyroxine (T-4). All subjects were stabilized on the minimum dose of T-4 which was necessary to suppress their serum thyroid-stimulating hormone (TSH) concentration to normal, and on this...
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| Veröffentlicht in: | BMJ 1973-07, Vol.3 (5872), p.131-134 |
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| creator | Evered, David Young, E. T. Ormston, B. J. Menzies, Ruth Smith, P. A. Hall, Reginald |
| description | Twenty-two subjects with hypothyroidism have been studied in detail before and during replacement therapy with L-thyroxine (T-4). All subjects were stabilized on the minimum dose of T-4 which was necessary to suppress their serum thyroid-stimulating hormone (TSH) concentration to normal, and on this dose most subjects had a normal or impaired TSH response to thyrotrophin-releasing hormone (TRH). The daily dose of T-4 required to suppress TSH was 0·1 mg (13 subjects), 0·15 mg (six subjects), and 0·2 mg (three subjects). It was shown that all subjects were euthyroid on these doses and, using a range of thyroid function tests, that they were normal in all respects when compared with a group of euthyroid controls, with the exception of a small group who had a marginally raised serum triiodo-L-thyronine (T-3) concentration. It has been shown that those subjects who required the larger doses of T-4 had a more advanced degree of thyroid failure than those who were stabilized on 0·1 mg T-4 daily. It is concluded that conventional doses of T-4 (0·2-0·4 mg daily) are often associated with subclinical hyperthyroidism. |
| doi_str_mv | 10.1136/bmj.3.5872.131 |
| format | Article |
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T. ; Ormston, B. J. ; Menzies, Ruth ; Smith, P. A. ; Hall, Reginald</creator><creatorcontrib>Evered, David ; Young, E. T. ; Ormston, B. J. ; Menzies, Ruth ; Smith, P. A. ; Hall, Reginald</creatorcontrib><description>Twenty-two subjects with hypothyroidism have been studied in detail before and during replacement therapy with L-thyroxine (T-4). All subjects were stabilized on the minimum dose of T-4 which was necessary to suppress their serum thyroid-stimulating hormone (TSH) concentration to normal, and on this dose most subjects had a normal or impaired TSH response to thyrotrophin-releasing hormone (TRH). The daily dose of T-4 required to suppress TSH was 0·1 mg (13 subjects), 0·15 mg (six subjects), and 0·2 mg (three subjects). It was shown that all subjects were euthyroid on these doses and, using a range of thyroid function tests, that they were normal in all respects when compared with a group of euthyroid controls, with the exception of a small group who had a marginally raised serum triiodo-L-thyronine (T-3) concentration. It has been shown that those subjects who required the larger doses of T-4 had a more advanced degree of thyroid failure than those who were stabilized on 0·1 mg T-4 daily. It is concluded that conventional doses of T-4 (0·2-0·4 mg daily) are often associated with subclinical hyperthyroidism.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.3.5872.131</identifier><identifier>PMID: 4720761</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Biochemistry ; Endocrinology ; Hormones ; Humans ; Hyperthyroidism ; Hypothyroidism ; Hypothyroidism - drug therapy ; Iodine Isotopes ; Medical journals ; Medical research ; Papers and Originals ; Serum cholesterol ; Symptoms ; Thyroid Function Tests ; Thyroid hormones ; Thyroidectomy ; Thyrotropin - blood ; Thyroxine - therapeutic use ; Triiodothyronine - blood</subject><ispartof>BMJ, 1973-07, Vol.3 (5872), p.131-134</ispartof><rights>Copyright 1973 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Jul 21, 1973</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-368be913d933066b991b45914b0e4410f0b02d88fc649b2e2d72af1c72ee02bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25420722$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25420722$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4720761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evered, David</creatorcontrib><creatorcontrib>Young, E. T.</creatorcontrib><creatorcontrib>Ormston, B. J.</creatorcontrib><creatorcontrib>Menzies, Ruth</creatorcontrib><creatorcontrib>Smith, P. A.</creatorcontrib><creatorcontrib>Hall, Reginald</creatorcontrib><title>Treatment of Hypothyroidism: A Reappraisal of Thyroxine Therapy</title><title>BMJ</title><addtitle>Br Med J</addtitle><description>Twenty-two subjects with hypothyroidism have been studied in detail before and during replacement therapy with L-thyroxine (T-4). All subjects were stabilized on the minimum dose of T-4 which was necessary to suppress their serum thyroid-stimulating hormone (TSH) concentration to normal, and on this dose most subjects had a normal or impaired TSH response to thyrotrophin-releasing hormone (TRH). The daily dose of T-4 required to suppress TSH was 0·1 mg (13 subjects), 0·15 mg (six subjects), and 0·2 mg (three subjects). It was shown that all subjects were euthyroid on these doses and, using a range of thyroid function tests, that they were normal in all respects when compared with a group of euthyroid controls, with the exception of a small group who had a marginally raised serum triiodo-L-thyronine (T-3) concentration. It has been shown that those subjects who required the larger doses of T-4 had a more advanced degree of thyroid failure than those who were stabilized on 0·1 mg T-4 daily. It is concluded that conventional doses of T-4 (0·2-0·4 mg daily) are often associated with subclinical hyperthyroidism.</description><subject>Biochemistry</subject><subject>Endocrinology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hyperthyroidism</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - drug therapy</subject><subject>Iodine Isotopes</subject><subject>Medical journals</subject><subject>Medical research</subject><subject>Papers and Originals</subject><subject>Serum cholesterol</subject><subject>Symptoms</subject><subject>Thyroid Function Tests</subject><subject>Thyroid hormones</subject><subject>Thyroidectomy</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - therapeutic use</subject><subject>Triiodothyronine - blood</subject><issn>0007-1447</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1rFDEYh4Modam9ehMWBMHDjHmTTD48KGWxrVAqlNVrSGYyNuvMZJrMSve_b8Zd1o-LpyQ8D7_8khehl4BLAMrf2X5T0rKSgpRA4QlaAOOyqCSlT9ECYywKYEw8R2cpbfKRUCEVZyfohAmCBYcF-riOzky9G6ZlaJdXuzFMd7sYfONT_355vrx1Zhyj8cl0s7Ce4YMfXN65aMbdC_SsNV1yZ4f1FH29-LReXRXXXy4_r86vC1thMRWUS-sU0EZRijm3SoFllQJmsWMMcIstJo2Ubc2ZssSRRhDTQi2Ic5jYmp6iD_vccWt719S5cDSdHqPvTdzpYLz-mwz-Tn8PPzVUklMKOeDNISCG-61Lk-59ql3XmcGFbdISlORYVVl8_Y-4Cds45MdpEPnPcE6T2Sr3Vh1DStG1xyqA9TwbnWejqZ5no-HX_a_-fMBRP0ziN9-kKcQjJhXLnJDMiz33aXIPR27iD80FFZW--bbSN2wtbi856Nl_u_fnHv_p9gisma8O</recordid><startdate>19730721</startdate><enddate>19730721</enddate><creator>Evered, David</creator><creator>Young, E. 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A. ; Hall, Reginald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b507t-368be913d933066b991b45914b0e4410f0b02d88fc649b2e2d72af1c72ee02bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Biochemistry</topic><topic>Endocrinology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hyperthyroidism</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - drug therapy</topic><topic>Iodine Isotopes</topic><topic>Medical journals</topic><topic>Medical research</topic><topic>Papers and Originals</topic><topic>Serum cholesterol</topic><topic>Symptoms</topic><topic>Thyroid Function Tests</topic><topic>Thyroid hormones</topic><topic>Thyroidectomy</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - therapeutic use</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evered, David</creatorcontrib><creatorcontrib>Young, E. 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T.</au><au>Ormston, B. J.</au><au>Menzies, Ruth</au><au>Smith, P. A.</au><au>Hall, Reginald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Hypothyroidism: A Reappraisal of Thyroxine Therapy</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J</addtitle><date>1973-07-21</date><risdate>1973</risdate><volume>3</volume><issue>5872</issue><spage>131</spage><epage>134</epage><pages>131-134</pages><issn>0007-1447</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>Twenty-two subjects with hypothyroidism have been studied in detail before and during replacement therapy with L-thyroxine (T-4). All subjects were stabilized on the minimum dose of T-4 which was necessary to suppress their serum thyroid-stimulating hormone (TSH) concentration to normal, and on this dose most subjects had a normal or impaired TSH response to thyrotrophin-releasing hormone (TRH). The daily dose of T-4 required to suppress TSH was 0·1 mg (13 subjects), 0·15 mg (six subjects), and 0·2 mg (three subjects). It was shown that all subjects were euthyroid on these doses and, using a range of thyroid function tests, that they were normal in all respects when compared with a group of euthyroid controls, with the exception of a small group who had a marginally raised serum triiodo-L-thyronine (T-3) concentration. It has been shown that those subjects who required the larger doses of T-4 had a more advanced degree of thyroid failure than those who were stabilized on 0·1 mg T-4 daily. It is concluded that conventional doses of T-4 (0·2-0·4 mg daily) are often associated with subclinical hyperthyroidism.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>4720761</pmid><doi>10.1136/bmj.3.5872.131</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMJ, 1973-07, Vol.3 (5872), p.131-134 |
| issn | 0007-1447 0959-8138 1468-5833 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | Biochemistry Endocrinology Hormones Humans Hyperthyroidism Hypothyroidism Hypothyroidism - drug therapy Iodine Isotopes Medical journals Medical research Papers and Originals Serum cholesterol Symptoms Thyroid Function Tests Thyroid hormones Thyroidectomy Thyrotropin - blood Thyroxine - therapeutic use Triiodothyronine - blood |
| title | Treatment of Hypothyroidism: A Reappraisal of Thyroxine Therapy |
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