Characterization of the Purified Hyaluronan Synthase from Streptococcus equisimilis

Hyaluronan synthase (HAS) utilizes UDP-GlcUA and UDP-GlcNAc in the presence of Mg2+ to form the GAG hyaluronan (HA). The purified HAS from Streptococcus equisimilis (seHAS) shows high fidelity in that it only polymerizes the native substrates, UDP-GlcNAc and UDP-GlcUA. However, other uridinyl nucleo...

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Veröffentlicht in:	Biochemistry (Easton) 2004-07, Vol.43 (28), p.9234-9242
Hauptverfasser:	Tlapak-Simmons, Valarie L, Baron, Christina A, Weigel, Paul H
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiolipins - pharmacology Enzyme Stability Glucuronosyltransferase Hyaluronan Synthases Hydrogen-Ion Concentration Kinetics Potassium Chloride - pharmacology Sodium Chloride - pharmacology Streptococcus equi - enzymology Streptococcus equisimilis Substrate Specificity Temperature Transferases - chemistry Transferases - isolation & purification Transferases - metabolism Viscosity
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