4E-Binding Protein Phosphorylation and Eukaryotic Initiation Factor-4E Release Are Required for Airway Smooth Muscle Hypertrophy

The molecular mechanisms of airway smooth muscle hypertrophy, a feature of severe asthma, are poorly understood. We previously established a conditionally immortalized human bronchial smooth muscle cell line with a temperature-sensitive SV40 large T antigen. Temperature shift and loss of large T cau...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2005-08, Vol.33 (2), p.195-202
Hauptverfasser:	Zhou, Limei, Goldsmith, Adam M, Bentley, J. Kelley, Jia, Yue, Rodriguez, Michael L, Abe, Mark K, Fingar, Diane C, Hershenson, Marc B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Bronchi - drug effects Bronchi - metabolism Bronchi - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Enlargement - drug effects Cell Line Chromones - pharmacology Enzyme Inhibitors - pharmacology Eukaryotic Initiation Factor-4E - metabolism Humans Hypertrophy Imidazoles - pharmacology Morpholines - pharmacology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - pathology Mutation p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein Kinases - drug effects Pyridines - pharmacology Sirolimus - pharmacology Temperature TOR Serine-Threonine Kinases Transfection
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