Carbonic Anhydrase Inhibitor Suppresses Invasion of Renal Cancer Cells in vitro

Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases (CAs), some of which are known to be overexpressed in certain cancers. To investigate the functional...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-02, Vol.97 (5), p.2220-2224
Hauptverfasser:	Parkkila, Seppo, Rajaniemi, Hannu, Parkkila, Anna-Kaisa, Kivela, Jyrki, Waheed, Abdul, Pastorekova, Silvia, Pastorek, Jaromir, Sly, William S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetazolamide Acetazolamide - pharmacology Acidification Amides Animals Antineoplastic Agents - pharmacology Biological Sciences Cancer Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - biosynthesis Cell growth Cell lines Cells Cultured cells Isoenzymes - biosynthesis Kidney cells Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Kidneys Medical research Mice Neoplasm Invasiveness Tumor Cells, Cultured Tumors Western blotting
Online-Zugang:	Volltext
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