Characterization of monoclonal antibody specific for human type II collagen: possible implication in collagen-induced arthritis
We obtained monoclonal antibodies specific for human type II collagen and characterized them using human collagen type I, II, III and V and tropocollagen A (3/4) (TCA) and tropocollagen B (1/4) (TCB) fragments of type II collagen which were obtained by digestion with tadpole collagenase. These antib...
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| Veröffentlicht in: | Clinical and experimental immunology 1985-10, Vol.62 (1), p.159-166 |
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| creator | HIROFUJI, T KAKIMOTO, K HORI, H NAGAI, Y SAISHO, K SUMIYOSHI, A KOGA, T |
| description | We obtained monoclonal antibodies specific for human type II collagen and characterized them using human collagen type I, II, III and V and tropocollagen A (3/4) (TCA) and tropocollagen B (1/4) (TCB) fragments of type II collagen which were obtained by digestion with tadpole collagenase. These antibodies were of the IgG2a class and specific for the conformational determinant of TCA fragment of type II collagen. When injected intravenously into DBA/1J mice, one of the monoclonal antibodies induced arthritis, which was characterized by early onset, mildness in severity and preferential localization mainly in the peripheral joints of the lower extremities. These results suggest that, at least, one of the arthritogenic determinants of type II collagen for collagen-induced arthritis of mice exists in the three quarter region from the N-terminus of type II collagen. |
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These antibodies were of the IgG2a class and specific for the conformational determinant of TCA fragment of type II collagen. When injected intravenously into DBA/1J mice, one of the monoclonal antibodies induced arthritis, which was characterized by early onset, mildness in severity and preferential localization mainly in the peripheral joints of the lower extremities. These results suggest that, at least, one of the arthritogenic determinants of type II collagen for collagen-induced arthritis of mice exists in the three quarter region from the N-terminus of type II collagen.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 2998657</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antibody Specificity ; Arthritis - etiology ; Arthritis - immunology ; Arthritis - pathology ; Biological and medical sciences ; Collagen - immunology ; Diseases of the osteoarticular system ; Electrophoresis, Polyacrylamide Gel ; Female ; Inflammatory joint diseases ; Joints - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred DBA ; Microbial Collagenase ; Peptide Fragments - immunology ; Peptide Fragments - isolation & purification</subject><ispartof>Clinical and experimental immunology, 1985-10, Vol.62 (1), p.159-166</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577398/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577398/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,53793,53795</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8463472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2998657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIROFUJI, T</creatorcontrib><creatorcontrib>KAKIMOTO, K</creatorcontrib><creatorcontrib>HORI, H</creatorcontrib><creatorcontrib>NAGAI, Y</creatorcontrib><creatorcontrib>SAISHO, K</creatorcontrib><creatorcontrib>SUMIYOSHI, A</creatorcontrib><creatorcontrib>KOGA, T</creatorcontrib><title>Characterization of monoclonal antibody specific for human type II collagen: possible implication in collagen-induced arthritis</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>We obtained monoclonal antibodies specific for human type II collagen and characterized them using human collagen type I, II, III and V and tropocollagen A (3/4) (TCA) and tropocollagen B (1/4) (TCB) fragments of type II collagen which were obtained by digestion with tadpole collagenase. These antibodies were of the IgG2a class and specific for the conformational determinant of TCA fragment of type II collagen. When injected intravenously into DBA/1J mice, one of the monoclonal antibodies induced arthritis, which was characterized by early onset, mildness in severity and preferential localization mainly in the peripheral joints of the lower extremities. These results suggest that, at least, one of the arthritogenic determinants of type II collagen for collagen-induced arthritis of mice exists in the three quarter region from the N-terminus of type II collagen.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibody Specificity</subject><subject>Arthritis - etiology</subject><subject>Arthritis - immunology</subject><subject>Arthritis - pathology</subject><subject>Biological and medical sciences</subject><subject>Collagen - immunology</subject><subject>Diseases of the osteoarticular system</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Female</subject><subject>Inflammatory joint diseases</subject><subject>Joints - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>Microbial Collagenase</subject><subject>Peptide Fragments - immunology</subject><subject>Peptide Fragments - isolation & purification</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhhtxWcd1f4KQg3hr6E7SSceDIIOrAwte3HNT-dopSSdtkhbGi399G3YY9OSpKN6Hh7eoF82uZ2JoKeXqZbPruk61qu_4q-Z1KT-2VQhBr5trqtQoBrlr_uyPkMFUl_E3VEyRJE_mFJMJKUIgECvqZE-kLM6gR0N8yuS4zhBJPS2OHA7EpBDg0cUPZEmloA6O4LwENM9CjBeixWhX4yyBXI8ZK5Y3zZWHUNzted40D3efv--_tvffvhz2n-7bhdG-tp4NvVFaas4GTTsP1hnLVCcsH5VXwjHNHTBtrRnk6K3TolPMM0uZF9z27Kb5-OxdVj07a1ysGcK0ZJwhn6YEOP2bRDxOj-nX1A9SMjVugvdnQU4_V1fqNGMxbrsrurSWSQou1Kjof8GeU0WlVBv49u9Kly7n32z5u3MOxUDwGaLBcsFGLhiXlD0BLIydng</recordid><startdate>19851001</startdate><enddate>19851001</enddate><creator>HIROFUJI, T</creator><creator>KAKIMOTO, K</creator><creator>HORI, H</creator><creator>NAGAI, Y</creator><creator>SAISHO, K</creator><creator>SUMIYOSHI, A</creator><creator>KOGA, T</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19851001</creationdate><title>Characterization of monoclonal antibody specific for human type II collagen: possible implication in collagen-induced arthritis</title><author>HIROFUJI, T ; KAKIMOTO, K ; HORI, H ; NAGAI, Y ; SAISHO, K ; SUMIYOSHI, A ; KOGA, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p321t-f351c9b7b435b20fadecd3906d489f96e3b4ea3bddc578fdeb6093f3d23f64d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibody Specificity</topic><topic>Arthritis - etiology</topic><topic>Arthritis - immunology</topic><topic>Arthritis - pathology</topic><topic>Biological and medical sciences</topic><topic>Collagen - immunology</topic><topic>Diseases of the osteoarticular system</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Female</topic><topic>Inflammatory joint diseases</topic><topic>Joints - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>Microbial Collagenase</topic><topic>Peptide Fragments - immunology</topic><topic>Peptide Fragments - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIROFUJI, T</creatorcontrib><creatorcontrib>KAKIMOTO, K</creatorcontrib><creatorcontrib>HORI, H</creatorcontrib><creatorcontrib>NAGAI, Y</creatorcontrib><creatorcontrib>SAISHO, K</creatorcontrib><creatorcontrib>SUMIYOSHI, A</creatorcontrib><creatorcontrib>KOGA, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIROFUJI, T</au><au>KAKIMOTO, K</au><au>HORI, H</au><au>NAGAI, Y</au><au>SAISHO, K</au><au>SUMIYOSHI, A</au><au>KOGA, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of monoclonal antibody specific for human type II collagen: possible implication in collagen-induced arthritis</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1985-10-01</date><risdate>1985</risdate><volume>62</volume><issue>1</issue><spage>159</spage><epage>166</epage><pages>159-166</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>We obtained monoclonal antibodies specific for human type II collagen and characterized them using human collagen type I, II, III and V and tropocollagen A (3/4) (TCA) and tropocollagen B (1/4) (TCB) fragments of type II collagen which were obtained by digestion with tadpole collagenase. These antibodies were of the IgG2a class and specific for the conformational determinant of TCA fragment of type II collagen. When injected intravenously into DBA/1J mice, one of the monoclonal antibodies induced arthritis, which was characterized by early onset, mildness in severity and preferential localization mainly in the peripheral joints of the lower extremities. These results suggest that, at least, one of the arthritogenic determinants of type II collagen for collagen-induced arthritis of mice exists in the three quarter region from the N-terminus of type II collagen.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>2998657</pmid><tpages>8</tpages></addata></record> |
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| subjects | Animals Antibodies, Monoclonal - immunology Antibody Specificity Arthritis - etiology Arthritis - immunology Arthritis - pathology Biological and medical sciences Collagen - immunology Diseases of the osteoarticular system Electrophoresis, Polyacrylamide Gel Female Inflammatory joint diseases Joints - pathology Male Medical sciences Mice Mice, Inbred DBA Microbial Collagenase Peptide Fragments - immunology Peptide Fragments - isolation & purification |
| title | Characterization of monoclonal antibody specific for human type II collagen: possible implication in collagen-induced arthritis |
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