Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors
Live mycobacteria are more efficient vaccines against mycobacterial disease than killed ones. A possible explanation is the existence of important protective antigens released by live bacilli, which are not present in any significant quantity in dead ones. Conversely, internal mycobacterial antigens...
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| Veröffentlicht in: | Clinical and experimental immunology 1986, Vol.63 (1), p.105-110 |
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| container_title | Clinical and experimental immunology |
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| creator | ROOK, G. A. W STEELE, J BARNASS, S MACE, J STANFORD, J. L |
| description | Live mycobacteria are more efficient vaccines against mycobacterial disease than killed ones. A possible explanation is the existence of important protective antigens released by live bacilli, which are not present in any significant quantity in dead ones. Conversely, internal mycobacterial antigens may be irrelevant to protection if not released by live bacilli. We show here, using T cell lines derived by limiting dilution from the peripheral blood of normal donors stimulated with sonicated BCG, that a variable percentage of sonicate responsive T cells is unable to respond to live M. tuberculosis. The possibility that such lines have an immunopathological, rather than protective role, is discussed. |
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We show here, using T cell lines derived by limiting dilution from the peripheral blood of normal donors stimulated with sonicated BCG, that a variable percentage of sonicate responsive T cells is unable to respond to live M. tuberculosis. The possibility that such lines have an immunopathological, rather than protective role, is discussed.</description><subject>Antigens, Bacterial - immunology</subject><subject>Bacteriology</subject><subject>Biogenesis of cell structures, supramolecular organization</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Microbiology</subject><subject>Mycobacterium - immunology</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Nontuberculous Mycobacteria - immunology</subject><subject>Sonication</subject><subject>T-Lymphocytes - immunology</subject><subject>Ultrasonics</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1LxDAQDaKs6-pPEHIQT1bSfDYXQcQvUARZzyWbJhpJk7XTCv57Iy6iJ4eBeTPv8ZhhttC8ZlJUlHK9jeaEEF3pmvBdtAfwWlopJZ2hGSMNFZzPETw6WOcE4d0lB4DHjGPB-P4Uj9PKDXaKGQKcYJM6bHPf51TgGJ5dKsPsMeQUrBldBWPop1hQh5fYuhiLUbHEfsg9TnnoTcRdLgD20Y43EdzBpi7Q09Xl8uKmunu4vr04v6vWlMmxcqKjnPGGG6eJULrzklqqqW68a6Rvaq9WWqra19ayuiOKu5UUTAjVaS0JYQt09u27nla966xL42Biux5Cb4aPNpvQ_mVSeGmf83tbC6VYiQU63hgM-W1yMLZ9gK_TTHJ5glZJJTkV9F9hzVlJyYvw8PdKP7ts_lH4ow1vwJroB5NsgB9ZU77XKMo-AeGHlko</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>ROOK, G. 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Psychology</topic><topic>Humans</topic><topic>Lymphocyte Activation</topic><topic>Microbiology</topic><topic>Mycobacterium - immunology</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - immunology</topic><topic>Nontuberculous Mycobacteria - immunology</topic><topic>Sonication</topic><topic>T-Lymphocytes - immunology</topic><topic>Ultrasonics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROOK, G. A. W</creatorcontrib><creatorcontrib>STEELE, J</creatorcontrib><creatorcontrib>BARNASS, S</creatorcontrib><creatorcontrib>MACE, J</creatorcontrib><creatorcontrib>STANFORD, J. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1986</date><risdate>1986</risdate><volume>63</volume><issue>1</issue><spage>105</spage><epage>110</epage><pages>105-110</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>Live mycobacteria are more efficient vaccines against mycobacterial disease than killed ones. A possible explanation is the existence of important protective antigens released by live bacilli, which are not present in any significant quantity in dead ones. Conversely, internal mycobacterial antigens may be irrelevant to protection if not released by live bacilli. We show here, using T cell lines derived by limiting dilution from the peripheral blood of normal donors stimulated with sonicated BCG, that a variable percentage of sonicate responsive T cells is unable to respond to live M. tuberculosis. The possibility that such lines have an immunopathological, rather than protective role, is discussed.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>3082544</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Clinical and experimental immunology, 1986, Vol.63 (1), p.105-110 |
| issn | 0009-9104 1365-2249 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1577333 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antigens, Bacterial - immunology Bacteriology Biogenesis of cell structures, supramolecular organization Biological and medical sciences Cell Line Fundamental and applied biological sciences. Psychology Humans Lymphocyte Activation Microbiology Mycobacterium - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Nontuberculous Mycobacteria - immunology Sonication T-Lymphocytes - immunology Ultrasonics |
| title | Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors |
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