Depressed classical complement pathway activities in chronic lymphocytic leukaemia
Haemolytic activities of the classical and alternative complement pathways, and levels of C1, C4, C3, factor B and C1 inhibitor (C1-INH) were measured in 85 serum samples from 46 patients with chronic lymphocytic leukaemia (CLL). Significantly decreased mean C1 and C4 levels were found, and the haem...
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| Veröffentlicht in: | Clinical and experimental immunology 1985-06, Vol.60 (3), p.489-495 |
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| container_title | Clinical and experimental immunology |
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| creator | FUST, G CZINK, E MINH, D MISZLAY, Z VARGA, L HOLLAN, S. R |
| description | Haemolytic activities of the classical and alternative complement pathways, and levels of C1, C4, C3, factor B and C1 inhibitor (C1-INH) were measured in 85 serum samples from 46 patients with chronic lymphocytic leukaemia (CLL). Significantly decreased mean C1 and C4 levels were found, and the haemolytic activities of these components were low or low normal in more than 50% of the sera tested. In 15 sera from 5 patients a complement profile characteristic of acquired C1-IHN deficiency was observed. These results indicate that the depression of the activity of the classical complement pathway is a frequently occurring feature in CLL. |
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These results indicate that the depression of the activity of the classical complement pathway is a frequently occurring feature in CLL.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 4017286</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Antigen-Antibody Complex - metabolism ; Biological and medical sciences ; Complement Activation ; Complement C1 - immunology ; Complement C1 Inactivator Proteins - deficiency ; Complement C3 - immunology ; Complement C4 - immunology ; Complement Pathway, Alternative ; Complement Pathway, Classical ; Hematologic and hematopoietic diseases ; Hemolysis ; Humans ; Leukemia, Lymphoid - immunology ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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R</creatorcontrib><title>Depressed classical complement pathway activities in chronic lymphocytic leukaemia</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Haemolytic activities of the classical and alternative complement pathways, and levels of C1, C4, C3, factor B and C1 inhibitor (C1-INH) were measured in 85 serum samples from 46 patients with chronic lymphocytic leukaemia (CLL). Significantly decreased mean C1 and C4 levels were found, and the haemolytic activities of these components were low or low normal in more than 50% of the sera tested. In 15 sera from 5 patients a complement profile characteristic of acquired C1-IHN deficiency was observed. These results indicate that the depression of the activity of the classical complement pathway is a frequently occurring feature in CLL.</description><subject>Antigen-Antibody Complex - metabolism</subject><subject>Biological and medical sciences</subject><subject>Complement Activation</subject><subject>Complement C1 - immunology</subject><subject>Complement C1 Inactivator Proteins - deficiency</subject><subject>Complement C3 - immunology</subject><subject>Complement C4 - immunology</subject><subject>Complement Pathway, Alternative</subject><subject>Complement Pathway, Classical</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Leukemia, Lymphoid - immunology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElLxEAQhRtRxnH0Jwg5iLdAb-nlIsi4woAgeg6dTsW0dhbTyUj-vRkMg548VRXv8erjHaAlYSKJKeX6EC0xxjrWBPNjdBLC-3QKIegCLTgmkiqxRM830HYQAuSR9SYEZ42PbFO1Hiqo-6g1ffllxsjY3m1d7yBEro5s2TW1s5Efq7Zs7Njvdhg-DFTOnKKjwvgAZ_Ncode725f1Q7x5un9cX2_illHSx4pgAgRAM2om2kzYRMqc54nmmgmmjFa84KzILcZ5JgvNCg5KaZFlQuqEsBW6-slth6yC3E64nfFp27nKdGPaGJf-VWpXpm_NNiXTI4r5FHA5B3TN5wChTysXLHhvamiGkEpBsZIK_2sknOJE0h3S-W-kPctc96RfzLoJU9FFZ2rrwt6midCCC_YNQVWLTA</recordid><startdate>19850601</startdate><enddate>19850601</enddate><creator>FUST, G</creator><creator>CZINK, E</creator><creator>MINH, D</creator><creator>MISZLAY, Z</creator><creator>VARGA, L</creator><creator>HOLLAN, S. 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Myelofibrosis</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUST, G</creatorcontrib><creatorcontrib>CZINK, E</creatorcontrib><creatorcontrib>MINH, D</creatorcontrib><creatorcontrib>MISZLAY, Z</creatorcontrib><creatorcontrib>VARGA, L</creatorcontrib><creatorcontrib>HOLLAN, S. 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R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depressed classical complement pathway activities in chronic lymphocytic leukaemia</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1985-06-01</date><risdate>1985</risdate><volume>60</volume><issue>3</issue><spage>489</spage><epage>495</epage><pages>489-495</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>Haemolytic activities of the classical and alternative complement pathways, and levels of C1, C4, C3, factor B and C1 inhibitor (C1-INH) were measured in 85 serum samples from 46 patients with chronic lymphocytic leukaemia (CLL). Significantly decreased mean C1 and C4 levels were found, and the haemolytic activities of these components were low or low normal in more than 50% of the sera tested. In 15 sera from 5 patients a complement profile characteristic of acquired C1-IHN deficiency was observed. These results indicate that the depression of the activity of the classical complement pathway is a frequently occurring feature in CLL.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>4017286</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Clinical and experimental immunology, 1985-06, Vol.60 (3), p.489-495 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antigen-Antibody Complex - metabolism Biological and medical sciences Complement Activation Complement C1 - immunology Complement C1 Inactivator Proteins - deficiency Complement C3 - immunology Complement C4 - immunology Complement Pathway, Alternative Complement Pathway, Classical Hematologic and hematopoietic diseases Hemolysis Humans Leukemia, Lymphoid - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences |
| title | Depressed classical complement pathway activities in chronic lymphocytic leukaemia |
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