Relationship between intensity of infection and immunomodulation in human schistosomiasis. I: Lymphocyte subpopulations and specific antibody responses
Cellular and humoral immune responsiveness in 44 Sudanese children with schistosomiasis was studied and related to the intensity of infection. The parasite load was quantitated by accurate assessment of the excretion of ova of S. mansoni and S. haematobium in stool and urine, respectively. Lymphocyt...
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| Veröffentlicht in: | Clinical and experimental immunology 1985-05, Vol.60 (2), p.225-233 |
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| creator | FELDMEIER, H GASTL, G. A POGGENSEE, U KORTMANN, C DAFFALLA, A. A PETER, H. H |
| description | Cellular and humoral immune responsiveness in 44 Sudanese children with schistosomiasis was studied and related to the intensity of infection. The parasite load was quantitated by accurate assessment of the excretion of ova of S. mansoni and S. haematobium in stool and urine, respectively. Lymphocyte subpopulations (T3+, T4+, T8+, TAC+, HNK1+, Ia+, SIg+, LGL+, ANAE+) as well as specific IgE and IgG antibodies to adult schistosome antigens were determined. The relationships existing between intensity of infection and cellular and humoral immune responsiveness revealed a distinct pattern of anti-parasite immunity: The percentage of pan-T cells (T3+) and the T helper (T4+):T suppressor (T8+) ratio were inversely correlated to the intensity of infection. In contrast, the percentage of T suppressor cells positively correlated to the parasite load. Ia+, TAC+, HNK1+ and T4+ cell counts did not show a significant relationship to worm burden. Specific IgE and IgG antibodies to S. mansoni and S. haematobium adult worm antigen clearly increased with the parasite load. The dichotomy of decreased T cell parameters and increased antibody response in heavily infected individuals represents a unique feature in helminthic infections. |
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I: Lymphocyte subpopulations and specific antibody responses</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>FELDMEIER, H ; GASTL, G. A ; POGGENSEE, U ; KORTMANN, C ; DAFFALLA, A. A ; PETER, H. H</creator><creatorcontrib>FELDMEIER, H ; GASTL, G. A ; POGGENSEE, U ; KORTMANN, C ; DAFFALLA, A. A ; PETER, H. H</creatorcontrib><description>Cellular and humoral immune responsiveness in 44 Sudanese children with schistosomiasis was studied and related to the intensity of infection. The parasite load was quantitated by accurate assessment of the excretion of ova of S. mansoni and S. haematobium in stool and urine, respectively. Lymphocyte subpopulations (T3+, T4+, T8+, TAC+, HNK1+, Ia+, SIg+, LGL+, ANAE+) as well as specific IgE and IgG antibodies to adult schistosome antigens were determined. The relationships existing between intensity of infection and cellular and humoral immune responsiveness revealed a distinct pattern of anti-parasite immunity: The percentage of pan-T cells (T3+) and the T helper (T4+):T suppressor (T8+) ratio were inversely correlated to the intensity of infection. In contrast, the percentage of T suppressor cells positively correlated to the parasite load. Ia+, TAC+, HNK1+ and T4+ cell counts did not show a significant relationship to worm burden. Specific IgE and IgG antibodies to S. mansoni and S. haematobium adult worm antigen clearly increased with the parasite load. The dichotomy of decreased T cell parameters and increased antibody response in heavily infected individuals represents a unique feature in helminthic infections.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 3159526</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Antibody Formation ; Antigens, Helminth - immunology ; Biological and medical sciences ; Child ; Diseases caused by trematodes ; Feces - parasitology ; Helminthic diseases ; Humans ; Immunity, Cellular ; Immunoglobulin E - biosynthesis ; Immunoglobulin G - biosynthesis ; Infectious diseases ; Leukocyte Count ; Lymphocytes - classification ; Lymphocytes - immunology ; Medical sciences ; Parasite Egg Count ; Parasitic diseases ; Schistosoma haematobium ; Schistosoma mansoni ; Schistosomiases ; Schistosomiasis - immunology ; Schistosomiasis - parasitology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Regulatory - immunology ; Tropical medicine</subject><ispartof>Clinical and experimental immunology, 1985-05, Vol.60 (2), p.225-233</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577032/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577032/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9252125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3159526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FELDMEIER, H</creatorcontrib><creatorcontrib>GASTL, G. A</creatorcontrib><creatorcontrib>POGGENSEE, U</creatorcontrib><creatorcontrib>KORTMANN, C</creatorcontrib><creatorcontrib>DAFFALLA, A. A</creatorcontrib><creatorcontrib>PETER, H. H</creatorcontrib><title>Relationship between intensity of infection and immunomodulation in human schistosomiasis. I: Lymphocyte subpopulations and specific antibody responses</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Cellular and humoral immune responsiveness in 44 Sudanese children with schistosomiasis was studied and related to the intensity of infection. The parasite load was quantitated by accurate assessment of the excretion of ova of S. mansoni and S. haematobium in stool and urine, respectively. Lymphocyte subpopulations (T3+, T4+, T8+, TAC+, HNK1+, Ia+, SIg+, LGL+, ANAE+) as well as specific IgE and IgG antibodies to adult schistosome antigens were determined. The relationships existing between intensity of infection and cellular and humoral immune responsiveness revealed a distinct pattern of anti-parasite immunity: The percentage of pan-T cells (T3+) and the T helper (T4+):T suppressor (T8+) ratio were inversely correlated to the intensity of infection. In contrast, the percentage of T suppressor cells positively correlated to the parasite load. Ia+, TAC+, HNK1+ and T4+ cell counts did not show a significant relationship to worm burden. Specific IgE and IgG antibodies to S. mansoni and S. haematobium adult worm antigen clearly increased with the parasite load. The dichotomy of decreased T cell parameters and increased antibody response in heavily infected individuals represents a unique feature in helminthic infections.</description><subject>Antibody Formation</subject><subject>Antigens, Helminth - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diseases caused by trematodes</subject><subject>Feces - parasitology</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunoglobulin E - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Infectious diseases</subject><subject>Leukocyte Count</subject><subject>Lymphocytes - classification</subject><subject>Lymphocytes - immunology</subject><subject>Medical sciences</subject><subject>Parasite Egg Count</subject><subject>Parasitic diseases</subject><subject>Schistosoma haematobium</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiases</subject><subject>Schistosomiasis - immunology</subject><subject>Schistosomiasis - parasitology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Tropical medicine</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuK1kAUhIMo4-_oIwi9EHeRvqU7cSHIMOrAD4LoOnR3TkxL-mJOR8mT-LrGmTDoytWh-KqKgvOgOjGhmppz2T2sTpTSru4YlY-rJ4jfdqmU4hfVhWBN13B1qn59gtkUnyJOPhML5SdAJD4WiOjLRtK4ixHcHwsxcSA-hDWmkIb1LrdjMq3BRIJu8lgSpuANenxFbl6T8xbylNxWgOBqc8pHCm-7MIPzo3e7KN6mYSMLYN4p4NPq0WhmhGfHvay-vLv-fPWhPn98f3P19lxnLlSpW-hAuoFyTh0DTSm02giplDaDbXUnleXCtUM7KCaZNUK4bjTUdsZqLZUUl9Wbu9682gCDg1gWM_d58cEsW5-M7_8l0U_91_SjZ43WVPC94OVRsKTvK2Dpg0cH82wipBV7rZgSkon_GpnkjLJb4_O_J91vOX628xcHN-jMPC4mOo_3to43nPFG_Aber6Zb</recordid><startdate>19850501</startdate><enddate>19850501</enddate><creator>FELDMEIER, H</creator><creator>GASTL, G. A</creator><creator>POGGENSEE, U</creator><creator>KORTMANN, C</creator><creator>DAFFALLA, A. A</creator><creator>PETER, H. H</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19850501</creationdate><title>Relationship between intensity of infection and immunomodulation in human schistosomiasis. I: Lymphocyte subpopulations and specific antibody responses</title><author>FELDMEIER, H ; GASTL, G. A ; POGGENSEE, U ; KORTMANN, C ; DAFFALLA, A. A ; PETER, H. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-8e9e4cd0220c1e700e87a34667adb87946b23c8d8d6141ba33c9fa0b9ab774643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Antibody Formation</topic><topic>Antigens, Helminth - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diseases caused by trematodes</topic><topic>Feces - parasitology</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunoglobulin E - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Infectious diseases</topic><topic>Leukocyte Count</topic><topic>Lymphocytes - classification</topic><topic>Lymphocytes - immunology</topic><topic>Medical sciences</topic><topic>Parasite Egg Count</topic><topic>Parasitic diseases</topic><topic>Schistosoma haematobium</topic><topic>Schistosoma mansoni</topic><topic>Schistosomiases</topic><topic>Schistosomiasis - immunology</topic><topic>Schistosomiasis - parasitology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FELDMEIER, H</creatorcontrib><creatorcontrib>GASTL, G. A</creatorcontrib><creatorcontrib>POGGENSEE, U</creatorcontrib><creatorcontrib>KORTMANN, C</creatorcontrib><creatorcontrib>DAFFALLA, A. A</creatorcontrib><creatorcontrib>PETER, H. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FELDMEIER, H</au><au>GASTL, G. A</au><au>POGGENSEE, U</au><au>KORTMANN, C</au><au>DAFFALLA, A. A</au><au>PETER, H. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between intensity of infection and immunomodulation in human schistosomiasis. I: Lymphocyte subpopulations and specific antibody responses</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1985-05-01</date><risdate>1985</risdate><volume>60</volume><issue>2</issue><spage>225</spage><epage>233</epage><pages>225-233</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>Cellular and humoral immune responsiveness in 44 Sudanese children with schistosomiasis was studied and related to the intensity of infection. The parasite load was quantitated by accurate assessment of the excretion of ova of S. mansoni and S. haematobium in stool and urine, respectively. Lymphocyte subpopulations (T3+, T4+, T8+, TAC+, HNK1+, Ia+, SIg+, LGL+, ANAE+) as well as specific IgE and IgG antibodies to adult schistosome antigens were determined. The relationships existing between intensity of infection and cellular and humoral immune responsiveness revealed a distinct pattern of anti-parasite immunity: The percentage of pan-T cells (T3+) and the T helper (T4+):T suppressor (T8+) ratio were inversely correlated to the intensity of infection. In contrast, the percentage of T suppressor cells positively correlated to the parasite load. Ia+, TAC+, HNK1+ and T4+ cell counts did not show a significant relationship to worm burden. Specific IgE and IgG antibodies to S. mansoni and S. haematobium adult worm antigen clearly increased with the parasite load. The dichotomy of decreased T cell parameters and increased antibody response in heavily infected individuals represents a unique feature in helminthic infections.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>3159526</pmid><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antibody Formation Antigens, Helminth - immunology Biological and medical sciences Child Diseases caused by trematodes Feces - parasitology Helminthic diseases Humans Immunity, Cellular Immunoglobulin E - biosynthesis Immunoglobulin G - biosynthesis Infectious diseases Leukocyte Count Lymphocytes - classification Lymphocytes - immunology Medical sciences Parasite Egg Count Parasitic diseases Schistosoma haematobium Schistosoma mansoni Schistosomiases Schistosomiasis - immunology Schistosomiasis - parasitology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Regulatory - immunology Tropical medicine |
| title | Relationship between intensity of infection and immunomodulation in human schistosomiasis. I: Lymphocyte subpopulations and specific antibody responses |
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