Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat
1 Since stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory diseases, many of which are sexually dimorphic, we tested whether the effect of stress on neutrophil recruitment, a primary component of the acute inflammatory response, is sexually dimorphic....
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| Veröffentlicht in: | British journal of pharmacology 2005-08, Vol.145 (7), p.872-879 |
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| creator | Barker, Laura A Dazin, Paul F Levine, Jon D Green, Paul G |
| description | 1
Since stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory diseases, many of which are sexually dimorphic, we tested whether the effect of stress on neutrophil recruitment, a primary component of the acute inflammatory response, is sexually dimorphic.
2
The effect of intermittent sound (over 4 days), a nonhabituating stress, on lipopolysaccharide (LPS)‐induced recruitment of neutrophils was evaluated in vivo in the rat air pouch model. At 24 h following the last stress exposure, LPS‐induced neutrophil recruitment was enhanced in male rats, but not in females.
3
When gonadectomized prepubertally and tested as adults, stress significantly inhibited the magnitude of LPS‐induced neutrophil recruitment in males, while it still had no effect in gonadectomized females. In males, following adrenal denervation, the increase in LPS‐induced neutrophil recruitment produced by stress was prevented. Since these data suggest that the effect of stress is dependent on the sympathoadrenal axis, we tested the hypothesis that catecholamines mediate the stress effects.
4
In male rats, the effect of stress on LPS‐induced neutrophil recruitment was significantly attenuated by continuous administration of the β‐adrenergic receptor antagonist, propranolol (4 mg kg−1 day−1), during sound stress exposure, and administration of isoproterenol (10 nmoles, i.v.) significantly increased neutrophil recruitment in males, an effect that was qualitatively and quantitatively similar to the effect of stress. Propranolol significantly increased neutrophil recruitment in nonstressed female rats, but did not significantly affect neutrophil recruitment in stressed females.
5
These findings indicate a marked male sex hormone‐dependent sexual dimorphism in the sympathoadrenal‐dependent effect of stress on neutrophil migration, a primary component of the inflammatory response, and suggest that the sympathoadrenal axis contributes to this effect via release of epinephrine.
British Journal of Pharmacology (2005) 145, 872–879. doi:10.1038/sj.bjp.0706257 |
| doi_str_mv | 10.1038/sj.bjp.0706257 |
| format | Article |
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Since stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory diseases, many of which are sexually dimorphic, we tested whether the effect of stress on neutrophil recruitment, a primary component of the acute inflammatory response, is sexually dimorphic.
2
The effect of intermittent sound (over 4 days), a nonhabituating stress, on lipopolysaccharide (LPS)‐induced recruitment of neutrophils was evaluated in vivo in the rat air pouch model. At 24 h following the last stress exposure, LPS‐induced neutrophil recruitment was enhanced in male rats, but not in females.
3
When gonadectomized prepubertally and tested as adults, stress significantly inhibited the magnitude of LPS‐induced neutrophil recruitment in males, while it still had no effect in gonadectomized females. In males, following adrenal denervation, the increase in LPS‐induced neutrophil recruitment produced by stress was prevented. Since these data suggest that the effect of stress is dependent on the sympathoadrenal axis, we tested the hypothesis that catecholamines mediate the stress effects.
4
In male rats, the effect of stress on LPS‐induced neutrophil recruitment was significantly attenuated by continuous administration of the β‐adrenergic receptor antagonist, propranolol (4 mg kg−1 day−1), during sound stress exposure, and administration of isoproterenol (10 nmoles, i.v.) significantly increased neutrophil recruitment in males, an effect that was qualitatively and quantitatively similar to the effect of stress. Propranolol significantly increased neutrophil recruitment in nonstressed female rats, but did not significantly affect neutrophil recruitment in stressed females.
5
These findings indicate a marked male sex hormone‐dependent sexual dimorphism in the sympathoadrenal‐dependent effect of stress on neutrophil migration, a primary component of the inflammatory response, and suggest that the sympathoadrenal axis contributes to this effect via release of epinephrine.
British Journal of Pharmacology (2005) 145, 872–879. doi:10.1038/sj.bjp.0706257</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0706257</identifier><identifier>PMID: 15912135</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acoustic Stimulation ; Adrenal Glands - immunology ; Adrenal Glands - innervation ; Adrenal medulla ; Adrenergic beta-Agonists - pharmacology ; Adrenergic beta-Antagonists - pharmacology ; Animals ; Biological and medical sciences ; Female ; Flow Cytometry ; Gonadal Steroid Hormones - immunology ; Inflammation - chemically induced ; Inflammation - immunology ; Isoproterenol - pharmacology ; Lipopolysaccharides ; Male ; Medical sciences ; Neutrophil Infiltration - drug effects ; Neutrophil Infiltration - immunology ; neutrophils ; Orchiectomy ; Ovariectomy ; Pharmacology. Drug treatments ; Propranolol - administration & dosage ; Propranolol - pharmacology ; Rats ; Rats, Sprague-Dawley ; sex differences ; Sex Factors ; Stress, Physiological - etiology ; Stress, Physiological - immunology ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - immunology ; β‐adrenergic receptor</subject><ispartof>British journal of pharmacology, 2005-08, Vol.145 (7), p.872-879</ispartof><rights>2005 British Pharmacological Society</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2005</rights><rights>Copyright 2005, Nature Publishing Group 2005 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4891-6fbd2fe5f2598ba1421d6c5aaf79129d7b94432e7eda3d9b176b16362c51f65a3</citedby><cites>FETCH-LOGICAL-c4891-6fbd2fe5f2598ba1421d6c5aaf79129d7b94432e7eda3d9b176b16362c51f65a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576213/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576213/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17013742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15912135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barker, Laura A</creatorcontrib><creatorcontrib>Dazin, Paul F</creatorcontrib><creatorcontrib>Levine, Jon D</creatorcontrib><creatorcontrib>Green, Paul G</creatorcontrib><title>Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
Since stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory diseases, many of which are sexually dimorphic, we tested whether the effect of stress on neutrophil recruitment, a primary component of the acute inflammatory response, is sexually dimorphic.
2
The effect of intermittent sound (over 4 days), a nonhabituating stress, on lipopolysaccharide (LPS)‐induced recruitment of neutrophils was evaluated in vivo in the rat air pouch model. At 24 h following the last stress exposure, LPS‐induced neutrophil recruitment was enhanced in male rats, but not in females.
3
When gonadectomized prepubertally and tested as adults, stress significantly inhibited the magnitude of LPS‐induced neutrophil recruitment in males, while it still had no effect in gonadectomized females. In males, following adrenal denervation, the increase in LPS‐induced neutrophil recruitment produced by stress was prevented. Since these data suggest that the effect of stress is dependent on the sympathoadrenal axis, we tested the hypothesis that catecholamines mediate the stress effects.
4
In male rats, the effect of stress on LPS‐induced neutrophil recruitment was significantly attenuated by continuous administration of the β‐adrenergic receptor antagonist, propranolol (4 mg kg−1 day−1), during sound stress exposure, and administration of isoproterenol (10 nmoles, i.v.) significantly increased neutrophil recruitment in males, an effect that was qualitatively and quantitatively similar to the effect of stress. Propranolol significantly increased neutrophil recruitment in nonstressed female rats, but did not significantly affect neutrophil recruitment in stressed females.
5
These findings indicate a marked male sex hormone‐dependent sexual dimorphism in the sympathoadrenal‐dependent effect of stress on neutrophil migration, a primary component of the inflammatory response, and suggest that the sympathoadrenal axis contributes to this effect via release of epinephrine.
British Journal of Pharmacology (2005) 145, 872–879. doi:10.1038/sj.bjp.0706257</description><subject>Acoustic Stimulation</subject><subject>Adrenal Glands - immunology</subject><subject>Adrenal Glands - innervation</subject><subject>Adrenal medulla</subject><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gonadal Steroid Hormones - immunology</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - immunology</subject><subject>Isoproterenol - pharmacology</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neutrophil Infiltration - drug effects</subject><subject>Neutrophil Infiltration - immunology</subject><subject>neutrophils</subject><subject>Orchiectomy</subject><subject>Ovariectomy</subject><subject>Pharmacology. Drug treatments</subject><subject>Propranolol - administration & dosage</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>sex differences</subject><subject>Sex Factors</subject><subject>Stress, Physiological - etiology</subject><subject>Stress, Physiological - immunology</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - immunology</subject><subject>β‐adrenergic receptor</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU2L1TAUhoMoznV061KC4LLXJG2aZiPooI4woKCuQ5qPaUqb1CS9enHjT_A3-kvMcIujK1dn8T7nPR8vAI8x2mNUd8_TuO_HZY8Yaglld8AON6ytaN3hu2CHEGIVxl13Bh6kNCJUREbvgzNMOSa4pjvw_eNxXmQegtTReDn9-vFTm8V4bXyGyXxb5TQdoXZziMvgFDTWGpVhsNAHP8je5VVm569hytGkBIOHzsODOwTozZpjKF0TjEbF1eX5xrTIeTAwyvwQ3LNySubRVs_B5zevP11cVlfv3767eHlVqabjuGptr4k11BLKu17ihmDdKiqlZeUKrlnPm6Ymhhkta817zNoet3VLFMW2pbI-By9Ovsvaz0arskWUk1iim2U8iiCd-FfxbhDX4SAwZW15UzF4uhnE8GU1KYsxrLF8KwmCGeaE865A-xOkYkgpGvtnAEbiJiuRRlGyEltWpeHJ32vd4ls4BXi2ATIpOdkovXLplmMI16whhatP3Fc3meN_xopXHy4JL_6_AfLDsv8</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Barker, Laura A</creator><creator>Dazin, Paul F</creator><creator>Levine, Jon D</creator><creator>Green, Paul G</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>200508</creationdate><title>Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat</title><author>Barker, Laura A ; Dazin, Paul F ; Levine, Jon D ; Green, Paul G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4891-6fbd2fe5f2598ba1421d6c5aaf79129d7b94432e7eda3d9b176b16362c51f65a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acoustic Stimulation</topic><topic>Adrenal Glands - immunology</topic><topic>Adrenal Glands - innervation</topic><topic>Adrenal medulla</topic><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gonadal Steroid Hormones - immunology</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - immunology</topic><topic>Isoproterenol - pharmacology</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neutrophil Infiltration - drug effects</topic><topic>Neutrophil Infiltration - immunology</topic><topic>neutrophils</topic><topic>Orchiectomy</topic><topic>Ovariectomy</topic><topic>Pharmacology. Drug treatments</topic><topic>Propranolol - administration & dosage</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>sex differences</topic><topic>Sex Factors</topic><topic>Stress, Physiological - etiology</topic><topic>Stress, Physiological - immunology</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - immunology</topic><topic>β‐adrenergic receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barker, Laura A</creatorcontrib><creatorcontrib>Dazin, Paul F</creatorcontrib><creatorcontrib>Levine, Jon D</creatorcontrib><creatorcontrib>Green, Paul G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barker, Laura A</au><au>Dazin, Paul F</au><au>Levine, Jon D</au><au>Green, Paul G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2005-08</date><risdate>2005</risdate><volume>145</volume><issue>7</issue><spage>872</spage><epage>879</epage><pages>872-879</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
Since stress both activates the sympathoadrenal axis and profoundly affects inflammation and inflammatory diseases, many of which are sexually dimorphic, we tested whether the effect of stress on neutrophil recruitment, a primary component of the acute inflammatory response, is sexually dimorphic.
2
The effect of intermittent sound (over 4 days), a nonhabituating stress, on lipopolysaccharide (LPS)‐induced recruitment of neutrophils was evaluated in vivo in the rat air pouch model. At 24 h following the last stress exposure, LPS‐induced neutrophil recruitment was enhanced in male rats, but not in females.
3
When gonadectomized prepubertally and tested as adults, stress significantly inhibited the magnitude of LPS‐induced neutrophil recruitment in males, while it still had no effect in gonadectomized females. In males, following adrenal denervation, the increase in LPS‐induced neutrophil recruitment produced by stress was prevented. Since these data suggest that the effect of stress is dependent on the sympathoadrenal axis, we tested the hypothesis that catecholamines mediate the stress effects.
4
In male rats, the effect of stress on LPS‐induced neutrophil recruitment was significantly attenuated by continuous administration of the β‐adrenergic receptor antagonist, propranolol (4 mg kg−1 day−1), during sound stress exposure, and administration of isoproterenol (10 nmoles, i.v.) significantly increased neutrophil recruitment in males, an effect that was qualitatively and quantitatively similar to the effect of stress. Propranolol significantly increased neutrophil recruitment in nonstressed female rats, but did not significantly affect neutrophil recruitment in stressed females.
5
These findings indicate a marked male sex hormone‐dependent sexual dimorphism in the sympathoadrenal‐dependent effect of stress on neutrophil migration, a primary component of the inflammatory response, and suggest that the sympathoadrenal axis contributes to this effect via release of epinephrine.
British Journal of Pharmacology (2005) 145, 872–879. doi:10.1038/sj.bjp.0706257</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15912135</pmid><doi>10.1038/sj.bjp.0706257</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 2005-08, Vol.145 (7), p.872-879 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acoustic Stimulation Adrenal Glands - immunology Adrenal Glands - innervation Adrenal medulla Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Biological and medical sciences Female Flow Cytometry Gonadal Steroid Hormones - immunology Inflammation - chemically induced Inflammation - immunology Isoproterenol - pharmacology Lipopolysaccharides Male Medical sciences Neutrophil Infiltration - drug effects Neutrophil Infiltration - immunology neutrophils Orchiectomy Ovariectomy Pharmacology. Drug treatments Propranolol - administration & dosage Propranolol - pharmacology Rats Rats, Sprague-Dawley sex differences Sex Factors Stress, Physiological - etiology Stress, Physiological - immunology Sympathetic Nervous System - drug effects Sympathetic Nervous System - immunology β‐adrenergic receptor |
| title | Sympathoadrenal‐dependent sexually dimorphic effect of nonhabituating stress on in vivo neutrophil recruitment in the rat |
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