2‐Furoyl‐LIGRL‐NH2, a potent agonist for proteinase‐activated receptor‐2, as a gastric mucosal cytoprotective agent in mice

1 Proteinase‐activated receptor‐2 (PAR2), expressed in capsaicin‐sensitive sensory neurons, plays a protective role in gastric mucosa. The present study evaluated gastric mucosal cytoprotective effect of 2‐furoyl‐LIGRL‐NH2, a novel highly potent PAR2 agonist, in ddY mice and in wild‐type and PAR2‐kn...

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Veröffentlicht in:	British journal of pharmacology 2005-01, Vol.144 (2), p.212-219
Hauptverfasser:	Kawabata, Atsufumi, Oono, Yuko, Yonezawa, Daiki, Hiramatsu, Kaori, Inoi, Naoki, Sekiguchi, Fumiko, Honjo, Masami, Hirofuchi, Michiko, Kanke, Toru, Ishiwata, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	a potent PAR2 agonist Animals Biological and medical sciences Cytoprotection - drug effects Cytoprotection - physiology Dose-Response Relationship, Drug Female Gastric Mucosa - drug effects Gastric Mucosa - pathology gastric mucosal protection Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Oligopeptides - pharmacology PAR2‐knockout mouse Pharmacology. Drug treatments Proteinase‐activated receptor (PAR) Receptor, PAR-2 - agonists Receptor, PAR-2 - physiology salivation
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