Plant antibodies for immunotherapy
The original report of Hiatt (1989) initiated a wave of excitement at the realization that a complex mammalian protein such as immunoglobulin could be assembled within a plant cell. The general reaction was one of amazement, but interest in exploiting the possibilities arising from the discovery, fo...
Gespeichert in:
| Veröffentlicht in: | Plant physiology (Bethesda) 1995-10, Vol.109 (2), p.341-346 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 346 |
|---|---|
| container_issue | 2 |
| container_start_page | 341 |
| container_title | Plant physiology (Bethesda) |
| container_volume | 109 |
| creator | Ma, J.K.C. (Guy's Hospital, London, UK.) Hein, M.B |
| description | The original report of Hiatt (1989) initiated a wave of excitement at the realization that a complex mammalian protein such as immunoglobulin could be assembled within a plant cell. The general reaction was one of amazement, but interest in exploiting the possibilities arising from the discovery, for example to make antibodies of therapeutic value, has taken a considerable time to develop. In the meantime, other recombinant expression systems and traditional cell culture techniques have advanced and overcome some of their problems, particularly those associated with yields. Plants, however, still offer unique advantages, especially in their ability to match the protein assembly capabilities of mammalian cells (as demonstrated by the assembly of SIgA molecules), as well as to provide antibodies in bulk at low cost. In addition, the area of "immunization" of plants holds great promise and will surely be a field of enormous growth for the future. |
| doi_str_mv | 10.1104/pp.109.2.341 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_157595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4276811</jstor_id><sourcerecordid>4276811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-b7da964d2500c7d5946b8a0419b202986d2f02d5161e0761f5f158c16cac79c23</originalsourceid><addsrcrecordid>eNqFkM1L7DAUxYM88Y0fO1fig0HElTPemyZNsnAh4hcICuo6pGmqlbapSUfwvzdDh-G5chFy4fzuufceQvYR5ojAzvp-jqDmdJ4x3CAT5BmdUc7kHzIBSDVIqf6S7RjfAQAzZFtkSzAJWcYm5OixMd0wTa8ufFm7OK18mNZtu-j88OaC6b92yWZlmuj2Vv8Oebm-er68nd0_3NxdXtzPLBNymBWiNCpnJeUAVpRcsbyQBhiqggJVMi9pBbTkmKMDkWPFK-TSYm6NFcrSbIecj779omhdaV03BNPoPtStCV_am1r_VLr6Tb_6T41ccMVT_8mqP_iPhYuDbutoXZMOdH4RtRA8jaXyV5BJyRXiEjwdQRt8jMFV62UQ9DJ73fepVJrqlH3C__1_wBpehZ3045VuojVNFUxn67jGslyBxKXN4Yi9x8GHtcyoyEf5YJQr47V5Dcnh5UmJFGva-Bt3apyL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>48859118</pqid></control><display><type>article</type><title>Plant antibodies for immunotherapy</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Jstor Complete Legacy</source><source>Alma/SFX Local Collection</source><creator>Ma, J.K.C. (Guy's Hospital, London, UK.) ; Hein, M.B</creator><creatorcontrib>Ma, J.K.C. (Guy's Hospital, London, UK.) ; Hein, M.B</creatorcontrib><description>The original report of Hiatt (1989) initiated a wave of excitement at the realization that a complex mammalian protein such as immunoglobulin could be assembled within a plant cell. The general reaction was one of amazement, but interest in exploiting the possibilities arising from the discovery, for example to make antibodies of therapeutic value, has taken a considerable time to develop. In the meantime, other recombinant expression systems and traditional cell culture techniques have advanced and overcome some of their problems, particularly those associated with yields. Plants, however, still offer unique advantages, especially in their ability to match the protein assembly capabilities of mammalian cells (as demonstrated by the assembly of SIgA molecules), as well as to provide antibodies in bulk at low cost. In addition, the area of "immunization" of plants holds great promise and will surely be a field of enormous growth for the future.</description><identifier>ISSN: 0032-0889</identifier><identifier>EISSN: 1532-2548</identifier><identifier>DOI: 10.1104/pp.109.2.341</identifier><identifier>PMID: 7480334</identifier><identifier>CODEN: PPHYA5</identifier><language>eng</language><publisher>Rockville, MD: American Society of Plant Physiologists</publisher><subject>Animals ; ANTIBODIES ; Antibody Formation ; ANTICORPS ; ANTICUERPOS ; ANTIGEN ANTIBODY REACTIONS ; Biological and medical sciences ; biosynthesis ; Biotechnology ; EXPERIMENTACION ; EXPERIMENTATION ; Fundamental and applied biological sciences. Psychology ; GENE ; GENES ; GENETIC ENGINEERING ; Genetic technics ; GENIE GENETIQUE ; Humans ; Immunoglobulin A ; Immunoglobulin A - biosynthesis ; Immunoglobulin G ; Immunoglobulin G - biosynthesis ; immunoglobulin genes ; IMMUNOGLOBULIN STRUCTURAL GENES ; IMMUNOGLOBULINE ; IMMUNOGLOBULINS ; Immunoglobulins - biosynthesis ; IMMUNOTHERAPIE ; IMMUNOTHERAPY ; Industrial plants ; INGENIERIA GENETICA ; INMUNOGLOBULINA ; INMUNOTERAPIA ; laws and regulations ; MAMIFEROS ; MAMMALS ; MAMMIFERE ; Methods. Procedures. Technologies ; MOLECULAR CONFORMATION ; Molecules ; Monoclonal antibodies ; Plant cells ; PLANTAS TRANSGENICAS ; PLANTE TRANSGENIQUE ; Plants ; Plants, Genetically Modified ; PROTEINAS ; PROTEINE ; PROTEINS ; REACCION ANTIGENO-ANTICUERPO ; REACTION ANTIGENE ANTICORPS ; RECOMBINANT PROTEINS ; Recombinant Proteins - biosynthesis ; REGLAMENTACIONES ; REGLEMENTATION ; REGULATIONS ; Secretion ; STRUCTURE ACTIVITY RELATIONSHIPS ; Transgenic animals and transgenic plants ; TRANSGENIC PLANTS ; Update on Biotechnology</subject><ispartof>Plant physiology (Bethesda), 1995-10, Vol.109 (2), p.341-346</ispartof><rights>Copyright 1995 American Society of Plant Physiologists</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-b7da964d2500c7d5946b8a0419b202986d2f02d5161e0761f5f158c16cac79c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4276811$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4276811$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,778,782,801,883,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3690811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7480334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, J.K.C. (Guy's Hospital, London, UK.)</creatorcontrib><creatorcontrib>Hein, M.B</creatorcontrib><title>Plant antibodies for immunotherapy</title><title>Plant physiology (Bethesda)</title><addtitle>Plant Physiol</addtitle><description>The original report of Hiatt (1989) initiated a wave of excitement at the realization that a complex mammalian protein such as immunoglobulin could be assembled within a plant cell. The general reaction was one of amazement, but interest in exploiting the possibilities arising from the discovery, for example to make antibodies of therapeutic value, has taken a considerable time to develop. In the meantime, other recombinant expression systems and traditional cell culture techniques have advanced and overcome some of their problems, particularly those associated with yields. Plants, however, still offer unique advantages, especially in their ability to match the protein assembly capabilities of mammalian cells (as demonstrated by the assembly of SIgA molecules), as well as to provide antibodies in bulk at low cost. In addition, the area of "immunization" of plants holds great promise and will surely be a field of enormous growth for the future.</description><subject>Animals</subject><subject>ANTIBODIES</subject><subject>Antibody Formation</subject><subject>ANTICORPS</subject><subject>ANTICUERPOS</subject><subject>ANTIGEN ANTIBODY REACTIONS</subject><subject>Biological and medical sciences</subject><subject>biosynthesis</subject><subject>Biotechnology</subject><subject>EXPERIMENTACION</subject><subject>EXPERIMENTATION</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE</subject><subject>GENES</subject><subject>GENETIC ENGINEERING</subject><subject>Genetic technics</subject><subject>GENIE GENETIQUE</subject><subject>Humans</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>immunoglobulin genes</subject><subject>IMMUNOGLOBULIN STRUCTURAL GENES</subject><subject>IMMUNOGLOBULINE</subject><subject>IMMUNOGLOBULINS</subject><subject>Immunoglobulins - biosynthesis</subject><subject>IMMUNOTHERAPIE</subject><subject>IMMUNOTHERAPY</subject><subject>Industrial plants</subject><subject>INGENIERIA GENETICA</subject><subject>INMUNOGLOBULINA</subject><subject>INMUNOTERAPIA</subject><subject>laws and regulations</subject><subject>MAMIFEROS</subject><subject>MAMMALS</subject><subject>MAMMIFERE</subject><subject>Methods. Procedures. Technologies</subject><subject>MOLECULAR CONFORMATION</subject><subject>Molecules</subject><subject>Monoclonal antibodies</subject><subject>Plant cells</subject><subject>PLANTAS TRANSGENICAS</subject><subject>PLANTE TRANSGENIQUE</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>REACCION ANTIGENO-ANTICUERPO</subject><subject>REACTION ANTIGENE ANTICORPS</subject><subject>RECOMBINANT PROTEINS</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>REGLAMENTACIONES</subject><subject>REGLEMENTATION</subject><subject>REGULATIONS</subject><subject>Secretion</subject><subject>STRUCTURE ACTIVITY RELATIONSHIPS</subject><subject>Transgenic animals and transgenic plants</subject><subject>TRANSGENIC PLANTS</subject><subject>Update on Biotechnology</subject><issn>0032-0889</issn><issn>1532-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1L7DAUxYM88Y0fO1fig0HElTPemyZNsnAh4hcICuo6pGmqlbapSUfwvzdDh-G5chFy4fzuufceQvYR5ojAzvp-jqDmdJ4x3CAT5BmdUc7kHzIBSDVIqf6S7RjfAQAzZFtkSzAJWcYm5OixMd0wTa8ufFm7OK18mNZtu-j88OaC6b92yWZlmuj2Vv8Oebm-er68nd0_3NxdXtzPLBNymBWiNCpnJeUAVpRcsbyQBhiqggJVMi9pBbTkmKMDkWPFK-TSYm6NFcrSbIecj779omhdaV03BNPoPtStCV_am1r_VLr6Tb_6T41ccMVT_8mqP_iPhYuDbutoXZMOdH4RtRA8jaXyV5BJyRXiEjwdQRt8jMFV62UQ9DJ73fepVJrqlH3C__1_wBpehZ3045VuojVNFUxn67jGslyBxKXN4Yi9x8GHtcyoyEf5YJQr47V5Dcnh5UmJFGva-Bt3apyL</recordid><startdate>19951001</startdate><enddate>19951001</enddate><creator>Ma, J.K.C. (Guy's Hospital, London, UK.)</creator><creator>Hein, M.B</creator><general>American Society of Plant Physiologists</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19951001</creationdate><title>Plant antibodies for immunotherapy</title><author>Ma, J.K.C. (Guy's Hospital, London, UK.) ; Hein, M.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-b7da964d2500c7d5946b8a0419b202986d2f02d5161e0761f5f158c16cac79c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>ANTIBODIES</topic><topic>Antibody Formation</topic><topic>ANTICORPS</topic><topic>ANTICUERPOS</topic><topic>ANTIGEN ANTIBODY REACTIONS</topic><topic>Biological and medical sciences</topic><topic>biosynthesis</topic><topic>Biotechnology</topic><topic>EXPERIMENTACION</topic><topic>EXPERIMENTATION</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE</topic><topic>GENES</topic><topic>GENETIC ENGINEERING</topic><topic>Genetic technics</topic><topic>GENIE GENETIQUE</topic><topic>Humans</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>immunoglobulin genes</topic><topic>IMMUNOGLOBULIN STRUCTURAL GENES</topic><topic>IMMUNOGLOBULINE</topic><topic>IMMUNOGLOBULINS</topic><topic>Immunoglobulins - biosynthesis</topic><topic>IMMUNOTHERAPIE</topic><topic>IMMUNOTHERAPY</topic><topic>Industrial plants</topic><topic>INGENIERIA GENETICA</topic><topic>INMUNOGLOBULINA</topic><topic>INMUNOTERAPIA</topic><topic>laws and regulations</topic><topic>MAMIFEROS</topic><topic>MAMMALS</topic><topic>MAMMIFERE</topic><topic>Methods. Procedures. Technologies</topic><topic>MOLECULAR CONFORMATION</topic><topic>Molecules</topic><topic>Monoclonal antibodies</topic><topic>Plant cells</topic><topic>PLANTAS TRANSGENICAS</topic><topic>PLANTE TRANSGENIQUE</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>REACCION ANTIGENO-ANTICUERPO</topic><topic>REACTION ANTIGENE ANTICORPS</topic><topic>RECOMBINANT PROTEINS</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>REGLAMENTACIONES</topic><topic>REGLEMENTATION</topic><topic>REGULATIONS</topic><topic>Secretion</topic><topic>STRUCTURE ACTIVITY RELATIONSHIPS</topic><topic>Transgenic animals and transgenic plants</topic><topic>TRANSGENIC PLANTS</topic><topic>Update on Biotechnology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, J.K.C. (Guy's Hospital, London, UK.)</creatorcontrib><creatorcontrib>Hein, M.B</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Plant physiology (Bethesda)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, J.K.C. (Guy's Hospital, London, UK.)</au><au>Hein, M.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant antibodies for immunotherapy</atitle><jtitle>Plant physiology (Bethesda)</jtitle><addtitle>Plant Physiol</addtitle><date>1995-10-01</date><risdate>1995</risdate><volume>109</volume><issue>2</issue><spage>341</spage><epage>346</epage><pages>341-346</pages><issn>0032-0889</issn><eissn>1532-2548</eissn><coden>PPHYA5</coden><abstract>The original report of Hiatt (1989) initiated a wave of excitement at the realization that a complex mammalian protein such as immunoglobulin could be assembled within a plant cell. The general reaction was one of amazement, but interest in exploiting the possibilities arising from the discovery, for example to make antibodies of therapeutic value, has taken a considerable time to develop. In the meantime, other recombinant expression systems and traditional cell culture techniques have advanced and overcome some of their problems, particularly those associated with yields. Plants, however, still offer unique advantages, especially in their ability to match the protein assembly capabilities of mammalian cells (as demonstrated by the assembly of SIgA molecules), as well as to provide antibodies in bulk at low cost. In addition, the area of "immunization" of plants holds great promise and will surely be a field of enormous growth for the future.</abstract><cop>Rockville, MD</cop><pub>American Society of Plant Physiologists</pub><pmid>7480334</pmid><doi>10.1104/pp.109.2.341</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-0889 |
| ispartof | Plant physiology (Bethesda), 1995-10, Vol.109 (2), p.341-346 |
| issn | 0032-0889 1532-2548 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_157595 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Alma/SFX Local Collection |
| subjects | Animals ANTIBODIES Antibody Formation ANTICORPS ANTICUERPOS ANTIGEN ANTIBODY REACTIONS Biological and medical sciences biosynthesis Biotechnology EXPERIMENTACION EXPERIMENTATION Fundamental and applied biological sciences. Psychology GENE GENES GENETIC ENGINEERING Genetic technics GENIE GENETIQUE Humans Immunoglobulin A Immunoglobulin A - biosynthesis Immunoglobulin G Immunoglobulin G - biosynthesis immunoglobulin genes IMMUNOGLOBULIN STRUCTURAL GENES IMMUNOGLOBULINE IMMUNOGLOBULINS Immunoglobulins - biosynthesis IMMUNOTHERAPIE IMMUNOTHERAPY Industrial plants INGENIERIA GENETICA INMUNOGLOBULINA INMUNOTERAPIA laws and regulations MAMIFEROS MAMMALS MAMMIFERE Methods. Procedures. Technologies MOLECULAR CONFORMATION Molecules Monoclonal antibodies Plant cells PLANTAS TRANSGENICAS PLANTE TRANSGENIQUE Plants Plants, Genetically Modified PROTEINAS PROTEINE PROTEINS REACCION ANTIGENO-ANTICUERPO REACTION ANTIGENE ANTICORPS RECOMBINANT PROTEINS Recombinant Proteins - biosynthesis REGLAMENTACIONES REGLEMENTATION REGULATIONS Secretion STRUCTURE ACTIVITY RELATIONSHIPS Transgenic animals and transgenic plants TRANSGENIC PLANTS Update on Biotechnology |
| title | Plant antibodies for immunotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T02%3A46%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plant%20antibodies%20for%20immunotherapy&rft.jtitle=Plant%20physiology%20(Bethesda)&rft.au=Ma,%20J.K.C.%20(Guy's%20Hospital,%20London,%20UK.)&rft.date=1995-10-01&rft.volume=109&rft.issue=2&rft.spage=341&rft.epage=346&rft.pages=341-346&rft.issn=0032-0889&rft.eissn=1532-2548&rft.coden=PPHYA5&rft_id=info:doi/10.1104/pp.109.2.341&rft_dat=%3Cjstor_pubme%3E4276811%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=48859118&rft_id=info:pmid/7480334&rft_jstor_id=4276811&rfr_iscdi=true |