Nitric oxide donors inhibit 5‐hydroxytryptamine (5‐HT) uptake by the human 5‐HT transporter (SERT)

The aim was to test the hypothesis that nitric oxide (NO) donor drugs can inhibit the 5‐hydroxytryptamine (5‐HT) transporter, SERT. The NO donors, MAHMA/NO (a NONOate; (Z)‐1‐[N‐methyl‐N‐[6‐(N‐methylammoniohexyl)‐amino]]diazen‐1‐ium‐1,2‐diolate), SIN‐1 (a sydnonimine; 5‐amino‐3‐(4‐morpholinyl)‐1,2,3‐...

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Veröffentlicht in:	British journal of pharmacology 2004-09, Vol.143 (1), p.63-70
Hauptverfasser:	Bryan‐Lluka, Lesley J, Papacostas, Marisa H, Paczkowski, Filip A, Wanstall, Janet C
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT transporter (SERT) 5‐Hydroxytryptamine Animals Biological and medical sciences Biological Transport - drug effects Catalase - pharmacology Cercopithecus aethiops COS Cells Culture Media Cysteine - pharmacology DNA, Complementary - genetics DNA, Complementary - metabolism dopamine transporter (DAT) Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology FK409 Free Radical Scavengers - pharmacology Guanylate Cyclase - antagonists & inhibitors Humans Hydroxocobalamin - pharmacology Medical sciences Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - metabolism Membrane Transport Modulators Membrane Transport Proteins - antagonists & inhibitors Membrane Transport Proteins - metabolism Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism nitric oxide donors Nitric Oxide Donors - pharmacology Nitro Compounds - pharmacology NONOates Oxadiazoles - pharmacology peroxynitrite Peroxynitrous Acid - pharmacology Pharmacology. Drug treatments Piperazines - pharmacology Quinoxalines - pharmacology Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins SIN‐1 Superoxide Dismutase - pharmacology transfected COS‐7 cells Transfection
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