KMUP‐1, a xanthine derivative, induces relaxation of guinea‐pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels

7‐[2‐[4‐(2‐chlorophenyl)piperazinyl]ethyl]‐1,3‐dimethylxanthine (KMUP‐1) produces tracheal relaxation, intracellular accumulation of cyclic nucleotides, inhibition of phosphodiesterases (PDEs) and activation of K+ channels. KMUP‐1 (0.01–100 μM) induced concentration‐dependent relaxation responses in...

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Veröffentlicht in:	British journal of pharmacology 2004-08, Vol.142 (7), p.1105-1114
Hauptverfasser:	Wu, Bin‐Nan, Lin, Rong‐Jyh, Lo, Yi‐Ching, Shen, Kuo‐Pyng, Wang, Chao‐Chuan, Lin, Young‐Tso, Chen, Ing‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured cyclic AMP Cyclic AMP - physiology Cyclic AMP-Dependent Protein Kinases - biosynthesis cyclic GMP Cyclic GMP - physiology Cyclic GMP-Dependent Protein Kinases - biosynthesis Dose-Response Relationship, Drug Guanylate Cyclase - antagonists & inhibitors Guinea Pigs In Vitro Techniques K+ channels KMUP‐1 Male Medical sciences Muscle Relaxation - drug effects Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Piperidines - pharmacology Potassium Channels - physiology Respiratory Function Tests Respiratory Mucosa - physiology soluble guanylate cyclase Trachea - drug effects Trachea - physiology tracheal smooth muscle cells Vasodilator Agents - pharmacology Xanthines - pharmacology
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