Alpha‐1D adrenoceptors are involved in reserpine‐induced supersensitivity of rat tail artery
We examined reserpine‐induced chemical denervation supersensitivity with special reference to alpha‐1 adrenoceptor (AR) subtypes. Chronic treatment with reserpine for 2 weeks depleted noradrenaline in the tail artery and spleen of rats. Noradrenaline in the thoracic aorta was negligible before and a...
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| Veröffentlicht in: | British journal of pharmacology 2004-06, Vol.142 (4), p.647-656 |
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| creator | Taki, Naoyuki Tanaka, Takashi Zhang, Li Suzuki, Fumiko Israilova, Malika Taniguchi, Takanobu Hiraizumi‐Hiraoka, Yasuko Shinozuka, Kazumasa Kunitomo, Masaru Muramatsu, Ikunobu |
| description | We examined reserpine‐induced chemical denervation supersensitivity with special reference to alpha‐1 adrenoceptor (AR) subtypes.
Chronic treatment with reserpine for 2 weeks depleted noradrenaline in the tail artery and spleen of rats. Noradrenaline in the thoracic aorta was negligible before and after reserpine treatment.
The treatment with reserpine produced supersensitivity in the contractile responses of the rat tail artery to phenylephrine, 5‐HT and KCl, resulting in leftward shift of concentration–response curves (11.6‐, 2.5‐ and 1.1‐fold at EC50 value, respectively). These results suggest a predominant sensitization of the alpha‐1 AR‐mediated response by reserpine treatment.
BMY 7378 at a concentration (30 nM) specific for blocking the alpha‐1D AR subtype, but not KMD‐3213 at a concentration (10 nM) selective for blocking the alpha‐1A AR subtype, inhibited the supersensitivity of the phenylephrine‐induced response in the reserpine‐treated artery. On the other hand, the response to phenylephrine in reserpine‐untreated artery was selectively inhibited by the same concentration of KMD‐3213, but not by BMY 7378. Prazosin, a subtype‐nonselective antagonist, blocked the responses to phenylephrine with the same potency, regardless of reserpine treatment.
In the thoracic aorta and spleen, no supersensitivity was produced in the responses to phenylephrine by reserpine treatment.
In a tissue segment‐binding study using [3H]‐prazosin, the total density and affinity of alpha‐1 ARs in the rat tail artery were not changed by treatment with reserpine. However, alpha‐1D AR with high affinity for BMY 7378 was significantly detected in reserpine‐treated tail artery, in contrast to untreated artery. Decreases in alpha‐1A AR with high affinity for KMD‐3213 and alpha‐1B AR with low affinities for KMD‐3213 and BMY 7378 were also estimated in reserpine‐treated tail artery.
Alpha‐1D AR mRNA in rat tail artery increased to three‐folds by reserpine treatment, whereas the levels of alpha‐1A and 1B mRNAs were not significantly changed.
The present results suggest that chronic treatment with reserpine affects the expression of alpha‐1 AR subtypes of rat tail artery and that the induction of alpha‐1D ARs with high affinity for catecholamines is in part associated with reserpine‐induced supersensitivity.
British Journal of Pharmacology (2004) 142, 647–656. doi:10.1038/sj.bjp.0705817 |
| doi_str_mv | 10.1038/sj.bjp.0705817 |
| format | Article |
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Chronic treatment with reserpine for 2 weeks depleted noradrenaline in the tail artery and spleen of rats. Noradrenaline in the thoracic aorta was negligible before and after reserpine treatment.
The treatment with reserpine produced supersensitivity in the contractile responses of the rat tail artery to phenylephrine, 5‐HT and KCl, resulting in leftward shift of concentration–response curves (11.6‐, 2.5‐ and 1.1‐fold at EC50 value, respectively). These results suggest a predominant sensitization of the alpha‐1 AR‐mediated response by reserpine treatment.
BMY 7378 at a concentration (30 nM) specific for blocking the alpha‐1D AR subtype, but not KMD‐3213 at a concentration (10 nM) selective for blocking the alpha‐1A AR subtype, inhibited the supersensitivity of the phenylephrine‐induced response in the reserpine‐treated artery. On the other hand, the response to phenylephrine in reserpine‐untreated artery was selectively inhibited by the same concentration of KMD‐3213, but not by BMY 7378. Prazosin, a subtype‐nonselective antagonist, blocked the responses to phenylephrine with the same potency, regardless of reserpine treatment.
In the thoracic aorta and spleen, no supersensitivity was produced in the responses to phenylephrine by reserpine treatment.
In a tissue segment‐binding study using [3H]‐prazosin, the total density and affinity of alpha‐1 ARs in the rat tail artery were not changed by treatment with reserpine. However, alpha‐1D AR with high affinity for BMY 7378 was significantly detected in reserpine‐treated tail artery, in contrast to untreated artery. Decreases in alpha‐1A AR with high affinity for KMD‐3213 and alpha‐1B AR with low affinities for KMD‐3213 and BMY 7378 were also estimated in reserpine‐treated tail artery.
Alpha‐1D AR mRNA in rat tail artery increased to three‐folds by reserpine treatment, whereas the levels of alpha‐1A and 1B mRNAs were not significantly changed.
The present results suggest that chronic treatment with reserpine affects the expression of alpha‐1 AR subtypes of rat tail artery and that the induction of alpha‐1D ARs with high affinity for catecholamines is in part associated with reserpine‐induced supersensitivity.
British Journal of Pharmacology (2004) 142, 647–656. doi:10.1038/sj.bjp.0705817</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0705817</identifier><identifier>PMID: 15159276</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>alpha‐1 adrenoceptor (AR) ; Animals ; Aorta, Thoracic - chemistry ; Aorta, Thoracic - drug effects ; Arteries - drug effects ; Arteries - metabolism ; Biological and medical sciences ; chemical denervation ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Hypersensitivity ; Gene Expression - drug effects ; Gene Expression - genetics ; Indoles - administration & dosage ; intact tissue segment binding ; Japan ; Male ; Medical sciences ; mRNA ; Pharmacology. Drug treatments ; Phenylephrine - pharmacology ; Piperazines - pharmacology ; Potassium Chloride - pharmacology ; Prazosin - pharmacology ; rat tail artery ; Rats ; Rats, Wistar ; Receptors, Adrenergic, alpha-1 - drug effects ; Receptors, Adrenergic, alpha-1 - physiology ; reserpine ; Reserpine - pharmacology ; RNA, Messenger ; Serotonin - pharmacology ; Spleen - chemistry ; Spleen - drug effects ; Supersensitivity ; Tail - blood supply ; Tail - drug effects ; Tail - metabolism ; Time Factors ; Tritium</subject><ispartof>British journal of pharmacology, 2004-06, Vol.142 (4), p.647-656</ispartof><rights>2004 British Pharmacological Society</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 2004</rights><rights>Copyright 2004, Nature Publishing Group 2004 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5533-b455d9ce9f7dc2f93b15e903250ddb6884583d3a2b88bdb26d4deb120d451733</citedby><cites>FETCH-LOGICAL-c5533-b455d9ce9f7dc2f93b15e903250ddb6884583d3a2b88bdb26d4deb120d451733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575040/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575040/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15939230$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15159276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taki, Naoyuki</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Suzuki, Fumiko</creatorcontrib><creatorcontrib>Israilova, Malika</creatorcontrib><creatorcontrib>Taniguchi, Takanobu</creatorcontrib><creatorcontrib>Hiraizumi‐Hiraoka, Yasuko</creatorcontrib><creatorcontrib>Shinozuka, Kazumasa</creatorcontrib><creatorcontrib>Kunitomo, Masaru</creatorcontrib><creatorcontrib>Muramatsu, Ikunobu</creatorcontrib><title>Alpha‐1D adrenoceptors are involved in reserpine‐induced supersensitivity of rat tail artery</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>We examined reserpine‐induced chemical denervation supersensitivity with special reference to alpha‐1 adrenoceptor (AR) subtypes.
Chronic treatment with reserpine for 2 weeks depleted noradrenaline in the tail artery and spleen of rats. Noradrenaline in the thoracic aorta was negligible before and after reserpine treatment.
The treatment with reserpine produced supersensitivity in the contractile responses of the rat tail artery to phenylephrine, 5‐HT and KCl, resulting in leftward shift of concentration–response curves (11.6‐, 2.5‐ and 1.1‐fold at EC50 value, respectively). These results suggest a predominant sensitization of the alpha‐1 AR‐mediated response by reserpine treatment.
BMY 7378 at a concentration (30 nM) specific for blocking the alpha‐1D AR subtype, but not KMD‐3213 at a concentration (10 nM) selective for blocking the alpha‐1A AR subtype, inhibited the supersensitivity of the phenylephrine‐induced response in the reserpine‐treated artery. On the other hand, the response to phenylephrine in reserpine‐untreated artery was selectively inhibited by the same concentration of KMD‐3213, but not by BMY 7378. Prazosin, a subtype‐nonselective antagonist, blocked the responses to phenylephrine with the same potency, regardless of reserpine treatment.
In the thoracic aorta and spleen, no supersensitivity was produced in the responses to phenylephrine by reserpine treatment.
In a tissue segment‐binding study using [3H]‐prazosin, the total density and affinity of alpha‐1 ARs in the rat tail artery were not changed by treatment with reserpine. However, alpha‐1D AR with high affinity for BMY 7378 was significantly detected in reserpine‐treated tail artery, in contrast to untreated artery. Decreases in alpha‐1A AR with high affinity for KMD‐3213 and alpha‐1B AR with low affinities for KMD‐3213 and BMY 7378 were also estimated in reserpine‐treated tail artery.
Alpha‐1D AR mRNA in rat tail artery increased to three‐folds by reserpine treatment, whereas the levels of alpha‐1A and 1B mRNAs were not significantly changed.
The present results suggest that chronic treatment with reserpine affects the expression of alpha‐1 AR subtypes of rat tail artery and that the induction of alpha‐1D ARs with high affinity for catecholamines is in part associated with reserpine‐induced supersensitivity.
British Journal of Pharmacology (2004) 142, 647–656. doi:10.1038/sj.bjp.0705817</description><subject>alpha‐1 adrenoceptor (AR)</subject><subject>Animals</subject><subject>Aorta, Thoracic - chemistry</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Arteries - drug effects</subject><subject>Arteries - metabolism</subject><subject>Biological and medical sciences</subject><subject>chemical denervation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug Hypersensitivity</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - genetics</subject><subject>Indoles - administration & dosage</subject><subject>intact tissue segment binding</subject><subject>Japan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mRNA</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - pharmacology</subject><subject>Piperazines - pharmacology</subject><subject>Potassium Chloride - pharmacology</subject><subject>Prazosin - pharmacology</subject><subject>rat tail artery</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Adrenergic, alpha-1 - drug effects</subject><subject>Receptors, Adrenergic, alpha-1 - physiology</subject><subject>reserpine</subject><subject>Reserpine - pharmacology</subject><subject>RNA, Messenger</subject><subject>Serotonin - pharmacology</subject><subject>Spleen - chemistry</subject><subject>Spleen - drug effects</subject><subject>Supersensitivity</subject><subject>Tail - blood supply</subject><subject>Tail - drug effects</subject><subject>Tail - metabolism</subject><subject>Time Factors</subject><subject>Tritium</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1v1DAQhi0EokvhyhFFSHDL4o84ti9IbfkoUiU49G4ce0IdZe1gJ4v2xk_gN_JLcLURFC6cZjTzzDszehF6SvCWYCZf5WHbDdMWC8wlEffQhjSirTmT5D7aYIxFTYiUJ-hRzgPGpSn4Q3RCOOGKinaDPp-N0435-f0HeVMZlyBEC9McU65MgsqHfRz34EpSJciQJh-gwD64xZZyXiZIGUL2s9_7-VDFvkpmrmbjxyIwQzo8Rg96M2Z4ssZTdP3u7fXFZX318f2Hi7Or2nLOWN01nDtlQfXCWdor1hEOCjPKsXNdK2XDJXPM0E7KznW0dY2DjlDsGk4EY6fo9VF2WrodOAthTmbUU_I7kw46Gq__7gR_o7_EvSZccNzgIvByFUjx6wJ51jufLYyjCRCXrNu2bYhQooDP_wGHuKRQftOUCKIUa1SBtkfIpphzgv73JQTrW-N0HnQxTq_GlYFnd-__g69OFeDFCphszdgnE6zPdzjFFGW3f7Aj982PcPjPWn3-6ZIyytgvtv619Q</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Taki, Naoyuki</creator><creator>Tanaka, Takashi</creator><creator>Zhang, Li</creator><creator>Suzuki, Fumiko</creator><creator>Israilova, Malika</creator><creator>Taniguchi, Takanobu</creator><creator>Hiraizumi‐Hiraoka, Yasuko</creator><creator>Shinozuka, Kazumasa</creator><creator>Kunitomo, Masaru</creator><creator>Muramatsu, Ikunobu</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200406</creationdate><title>Alpha‐1D adrenoceptors are involved in reserpine‐induced supersensitivity of rat tail artery</title><author>Taki, Naoyuki ; Tanaka, Takashi ; Zhang, Li ; Suzuki, Fumiko ; Israilova, Malika ; Taniguchi, Takanobu ; Hiraizumi‐Hiraoka, Yasuko ; Shinozuka, Kazumasa ; Kunitomo, Masaru ; Muramatsu, Ikunobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5533-b455d9ce9f7dc2f93b15e903250ddb6884583d3a2b88bdb26d4deb120d451733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>alpha‐1 adrenoceptor (AR)</topic><topic>Animals</topic><topic>Aorta, Thoracic - chemistry</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Arteries - drug effects</topic><topic>Arteries - metabolism</topic><topic>Biological and medical sciences</topic><topic>chemical denervation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug Hypersensitivity</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - genetics</topic><topic>Indoles - administration & dosage</topic><topic>intact tissue segment binding</topic><topic>Japan</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mRNA</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - pharmacology</topic><topic>Piperazines - pharmacology</topic><topic>Potassium Chloride - pharmacology</topic><topic>Prazosin - pharmacology</topic><topic>rat tail artery</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Adrenergic, alpha-1 - drug effects</topic><topic>Receptors, Adrenergic, alpha-1 - physiology</topic><topic>reserpine</topic><topic>Reserpine - pharmacology</topic><topic>RNA, Messenger</topic><topic>Serotonin - pharmacology</topic><topic>Spleen - chemistry</topic><topic>Spleen - drug effects</topic><topic>Supersensitivity</topic><topic>Tail - blood supply</topic><topic>Tail - drug effects</topic><topic>Tail - metabolism</topic><topic>Time Factors</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taki, Naoyuki</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Suzuki, Fumiko</creatorcontrib><creatorcontrib>Israilova, Malika</creatorcontrib><creatorcontrib>Taniguchi, Takanobu</creatorcontrib><creatorcontrib>Hiraizumi‐Hiraoka, Yasuko</creatorcontrib><creatorcontrib>Shinozuka, Kazumasa</creatorcontrib><creatorcontrib>Kunitomo, Masaru</creatorcontrib><creatorcontrib>Muramatsu, Ikunobu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taki, Naoyuki</au><au>Tanaka, Takashi</au><au>Zhang, Li</au><au>Suzuki, Fumiko</au><au>Israilova, Malika</au><au>Taniguchi, Takanobu</au><au>Hiraizumi‐Hiraoka, Yasuko</au><au>Shinozuka, Kazumasa</au><au>Kunitomo, Masaru</au><au>Muramatsu, Ikunobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha‐1D adrenoceptors are involved in reserpine‐induced supersensitivity of rat tail artery</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2004-06</date><risdate>2004</risdate><volume>142</volume><issue>4</issue><spage>647</spage><epage>656</epage><pages>647-656</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>We examined reserpine‐induced chemical denervation supersensitivity with special reference to alpha‐1 adrenoceptor (AR) subtypes.
Chronic treatment with reserpine for 2 weeks depleted noradrenaline in the tail artery and spleen of rats. Noradrenaline in the thoracic aorta was negligible before and after reserpine treatment.
The treatment with reserpine produced supersensitivity in the contractile responses of the rat tail artery to phenylephrine, 5‐HT and KCl, resulting in leftward shift of concentration–response curves (11.6‐, 2.5‐ and 1.1‐fold at EC50 value, respectively). These results suggest a predominant sensitization of the alpha‐1 AR‐mediated response by reserpine treatment.
BMY 7378 at a concentration (30 nM) specific for blocking the alpha‐1D AR subtype, but not KMD‐3213 at a concentration (10 nM) selective for blocking the alpha‐1A AR subtype, inhibited the supersensitivity of the phenylephrine‐induced response in the reserpine‐treated artery. On the other hand, the response to phenylephrine in reserpine‐untreated artery was selectively inhibited by the same concentration of KMD‐3213, but not by BMY 7378. Prazosin, a subtype‐nonselective antagonist, blocked the responses to phenylephrine with the same potency, regardless of reserpine treatment.
In the thoracic aorta and spleen, no supersensitivity was produced in the responses to phenylephrine by reserpine treatment.
In a tissue segment‐binding study using [3H]‐prazosin, the total density and affinity of alpha‐1 ARs in the rat tail artery were not changed by treatment with reserpine. However, alpha‐1D AR with high affinity for BMY 7378 was significantly detected in reserpine‐treated tail artery, in contrast to untreated artery. Decreases in alpha‐1A AR with high affinity for KMD‐3213 and alpha‐1B AR with low affinities for KMD‐3213 and BMY 7378 were also estimated in reserpine‐treated tail artery.
Alpha‐1D AR mRNA in rat tail artery increased to three‐folds by reserpine treatment, whereas the levels of alpha‐1A and 1B mRNAs were not significantly changed.
The present results suggest that chronic treatment with reserpine affects the expression of alpha‐1 AR subtypes of rat tail artery and that the induction of alpha‐1D ARs with high affinity for catecholamines is in part associated with reserpine‐induced supersensitivity.
British Journal of Pharmacology (2004) 142, 647–656. doi:10.1038/sj.bjp.0705817</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15159276</pmid><doi>10.1038/sj.bjp.0705817</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1575040 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | alpha‐1 adrenoceptor (AR) Animals Aorta, Thoracic - chemistry Aorta, Thoracic - drug effects Arteries - drug effects Arteries - metabolism Biological and medical sciences chemical denervation Dose-Response Relationship, Drug Drug Administration Schedule Drug Hypersensitivity Gene Expression - drug effects Gene Expression - genetics Indoles - administration & dosage intact tissue segment binding Japan Male Medical sciences mRNA Pharmacology. Drug treatments Phenylephrine - pharmacology Piperazines - pharmacology Potassium Chloride - pharmacology Prazosin - pharmacology rat tail artery Rats Rats, Wistar Receptors, Adrenergic, alpha-1 - drug effects Receptors, Adrenergic, alpha-1 - physiology reserpine Reserpine - pharmacology RNA, Messenger Serotonin - pharmacology Spleen - chemistry Spleen - drug effects Supersensitivity Tail - blood supply Tail - drug effects Tail - metabolism Time Factors Tritium |
| title | Alpha‐1D adrenoceptors are involved in reserpine‐induced supersensitivity of rat tail artery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T02%3A06%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alpha%E2%80%901D%20adrenoceptors%20are%20involved%20in%20reserpine%E2%80%90induced%20supersensitivity%20of%20rat%20tail%20artery&rft.jtitle=British%20journal%20of%20pharmacology&rft.au=Taki,%20Naoyuki&rft.date=2004-06&rft.volume=142&rft.issue=4&rft.spage=647&rft.epage=656&rft.pages=647-656&rft.issn=0007-1188&rft.eissn=1476-5381&rft.coden=BJPCBM&rft_id=info:doi/10.1038/sj.bjp.0705817&rft_dat=%3Cproquest_pubme%3E984047591%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217199349&rft_id=info:pmid/15159276&rfr_iscdi=true |