Antitussive activity of sigma‐1 receptor agonists in the guinea‐pig

Current antitussive medications have limited efficacy and often contain the opiate‐like agent dextromethorphan (DEX). The mechanism whereby DEX inhibits cough is ill defined. DEX displays affinity at both NMDA and sigma receptors, suggesting that the antitussive activity may involve central or perip...

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Veröffentlicht in:	British journal of pharmacology 2004-01, Vol.141 (2), p.233-240
Hauptverfasser:	Brown, Claire, Fezoui, Malika, Selig, William M, Schwartz, Carl E, Ellis, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antitussive Antitussive Agents - pharmacology Antitussive Agents - therapeutic use Biological and medical sciences Brain - drug effects Brain - metabolism cough Cough - drug therapy Cough - metabolism Dextromethorphan - pharmacology Dextromethorphan - therapeutic use Dose-Response Relationship, Drug Ethylenediamines - pharmacology Guinea Pigs guinea‐pig Male Medical sciences Pharmacology. Drug treatments Phenazocine - analogs & derivatives Phenazocine - pharmacology Phenazocine - therapeutic use Protein Binding - drug effects Protein Binding - physiology Receptors, sigma - agonists Receptors, sigma - metabolism Sigma-1 Receptor Sigma‐1 agonist
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