Chronic treatment of male rats with daidzein and 17β‐oestradiol induces the contribution of EDHF to endothelium‐dependent relaxation

We investigated the effect of chronic (7 days) treatment of male rats with the isoflavone daidzein (0.2 mg kg−1 sc per day) or 17β‐oestradiol (0.1 mg kg−1 sc per day) on the contribution of nitric oxide (NO), prostaglandins and endothelium‐derived hyperpolarising factor (EDHF) to endothelium‐depende...

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Veröffentlicht in:	British journal of pharmacology 2004-01, Vol.141 (2), p.322-328
Hauptverfasser:	Woodman, Owen L, Boujaoude, Mirna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Factors - physiology Daidzein Dose-Response Relationship, Drug EDHF endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology Estradiol - administration & dosage Isoflavones - administration & dosage Male Medical sciences oestrogen Pharmacology. Drug treatments potassium channels Rats Rats, Sprague-Dawley Vasodilation - drug effects Vasodilation - physiology
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