Alkylglycerol opening of the blood–brain barrier to small and large fluorescence markers in normal and C6 glioma‐bearing rats and isolated rat brain capillaries

The blood–brain barrier (BBB) represents the major impediment to successful delivery of therapeutic agents to target tissue within the central nervous system. Intracarotid alkylglycerols have been shown to increase the transfer of chemotherapeutics across the BBB. We investigated the spatial distrib...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2003-12, Vol.140 (7), p.1201-1210
Hauptverfasser:	Erdlenbruch, Bernhard, Alipour, Mehrnaz, Fricker, Gert, Miller, David S, Kugler, Wilfried, Eibl, Hansjörg, Lakomek, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylglycerol Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological and medical sciences Biomarkers, Tumor - metabolism Blood-Brain Barrier - drug effects blood–brain barrier Brain - drug effects Brain Neoplasms - metabolism Brain Neoplasms - pathology brain tumor Capillaries confocal microscopy drug delivery Fluorescein fluorescence markers Fluorescent Dyes Glioma - metabolism Glioma - pathology Glycerol - administration & dosage Glycerol - analogs & derivatives Glycerol - pharmacology Injections, Intra-Arterial Injections, Intraventricular Male Medical sciences methotrexate Methotrexate - administration & dosage Methotrexate - pharmacokinetics Mice Mice, Nude Microscopy, Confocal Neoplasm Transplantation Pharmacology. Drug treatments rat brain capillaries Rats Rats, Wistar tight junction Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!