Actions of LY341495 on metabotropic glutamate receptor‐mediated responses in the neonatal rat spinal cord

The group II metabotropic glutamate (mGlu) receptor antagonist (2S,1′S,2′S)‐2‐(2‐carboxycyclopropyl)‐2‐(9H‐xanthen‐9‐yl)glycine (LY341495) also has activity at group I and III mGlu receptors at higher concentrations and can be used to discriminate between mGlu receptor subtypes. We report the antago...

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Veröffentlicht in:	British journal of pharmacology 2003-05, Vol.139 (1), p.147-155
Hauptverfasser:	Howson, Patrick A, Jane, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	(S)‐2‐amino‐4‐phosphonobutanoic acid ACPT‐I Amino Acids - pharmacology Aminobutyrates - pharmacology Animals Animals, Newborn Biological and medical sciences Cyclopentanes - pharmacology In Vitro Techniques LY341495 L‐AP4 Medical sciences metabotropic glutamate receptors Motor Neurons - drug effects Motor Neurons - physiology Neonatal rat spinal cord Rats Receptors, AMPA - drug effects Receptors, Kainic Acid - drug effects Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Receptors, N-Methyl-D-Aspartate - drug effects Spinal Cord - drug effects Spinal Cord - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Time Factors Tricarboxylic Acids - pharmacology Xanthenes - pharmacology
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