Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery

In phenylephrine (PHE) (1 μM)‐precontracted superior mesenteric arteries from adult rats, low concentration of hydrogen peroxide (H2O2, 10–100 μM) caused only contraction, while high concentration of H2O2 (0.3–1 mM) caused a biphasic response: a transient contraction followed by a relaxation respons...

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Veröffentlicht in:	British journal of pharmacology 2003-03, Vol.138 (6), p.1085-1092
Hauptverfasser:	Gao, Yu‐Jing, Hirota, Simon, Zhang, Da‐Wei, Janssen, Luke J, Lee, Robert M K W
Format:	Artikel
Sprache:	eng
Schlagworte:	4‐Aminopyridine Animals Biological and medical sciences contraction Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology hydrogen peroxide Hydrogen Peroxide - pharmacology Male Medical sciences Mesenteric Arteries - drug effects mesenteric artery Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - drug effects Muscle Relaxation - physiology Muscle, Smooth, Vascular - physiology Phenylephrine - pharmacology Potassium Channel Blockers - pharmacology potassium channels Potassium Channels - drug effects Potassium Channels - physiology rat Rats Rats, Inbred WKY reactive oxygen species relaxation Thromboxane A2 - pharmacology Time Factors
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