Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells

Acetaminophen, an analgesic and antipyretic drug with weak antiinflammatory properties, has been suggested to act as a tissue‐selective inhibitor of prostaglandin H synthases (PGHSs) (e.g. COX‐1 and COX‐2) through its reducing activity, that is influenced by the different cellular levels of peroxide...

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Veröffentlicht in:	British journal of pharmacology 2003-02, Vol.138 (4), p.634-641
Hauptverfasser:	Sciulli, Maria G, Seta, Francesca, Tacconelli, Stefania, Capone, Marta L, Ricciotti, Emanuela, Pistritto, Giuseppa, Patrignani, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - pharmacology Adult Analgesics Biological and medical sciences Blood Cells - drug effects Blood Cells - metabolism Dose-Response Relationship, Drug Female Humans Male Medical sciences monocyte COX‐2 Neuropharmacology PGE‐synthase Pharmacology. Drug treatments platelet COX‐1 Prostaglandins - biosynthesis whole blood
Online-Zugang:	Volltext
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