Parathyroid hormone increases the sensitivity of inositol trisphosphate receptors by a mechanism that is independent of cyclic AMP

In fura 2‐loaded HEK‐293 cells stably expressing human type 1 parathyroid hormone (PTH) receptors, PTH potentiated the Ca2+ mobilization evoked by carbachol by >4 fold without itself increasing the intracellular [Ca2+]. PTH potentiated the Ca2+ release evoked by a cell‐permeant analogue of inosit...

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Veröffentlicht in:	British journal of pharmacology 2003-01, Vol.138 (1), p.81-90
Hauptverfasser:	Tovey, Stephen C, Goraya, Tasmina A, Taylor, Colin W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Ca2+ stores Calcium - metabolism Calcium Channels - metabolism Cell Line cyclic AMP Cyclic AMP - metabolism cytoskeleton Fundamental and applied biological sciences. Psychology Hormones. Regulation Humans Inositol 1,4,5-Trisphosphate - pharmacology Inositol 1,4,5-Trisphosphate Receptors inositol trisphosphate receptors parathyroid hormone Parathyroid Hormone - pharmacology protein kinase A Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - metabolism Thyroid. Parathyroid. Ultimobranchial body Vertebrates: endocrinology
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