Unproductive cleavage and the inactivation of protease‐activated receptor‐1 by trypsin in vascular endothelial cells

Using fura‐2 fluorometry of [Ca2+]i in response to thrombin, trypsin and protease‐activated receptor activating peptides (PAR‐APs), we determined whether trypsin cleaves protease‐activated receptor 1 (PAR1) and activates it in the endothelial cells of the porcine aortic valves and human umbilical ve...

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