Demonstration of functional M3‐muscarinic receptors in ventricular cardiomyocytes of adult rats

Muscarinic receptors (M‐receptors) in the mammalian heart are predominantly of the M2‐subtype. The aim of this study was to find out whether there might exist an additional myocardial non‐M2‐receptor. For this purpose, we assessed, in adult rat isolated ventricular cardiomyocytes, carbachol‐induced...

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Veröffentlicht in:	British journal of pharmacology 2003-01, Vol.138 (1), p.156-160
Hauptverfasser:	Pönicke, Klaus, Heinroth‐Hoffmann, Ingrid, Brodde, Otto‐Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biological and medical sciences carbachol Cell receptors Cell structures and functions darifenacin Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Heart Ventricles - cytology Heart Ventricles - drug effects Heart Ventricles - metabolism inositol phosphates Inositol Phosphates - metabolism M2‐receptors M3‐receptors Male Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology pertussis toxin Rat cardiomyocytes Rats Rats, Wistar Receptor, Muscarinic M3 Receptors, Muscarinic - physiology
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