Effects of non‐steroidal anti‐inflammatory drugs on cyclo‐oxygenase and lipoxygenase activity in whole blood from aspirin‐sensitive asthmatics vs healthy donors

Cyclo‐oxygenase (COX) and lipoxygenase (LO) share a common substrate, arachidonic acid. Aspirin and related drugs inhibit COX activity. In a subset of patients with asthma aspirin induces clinical symptoms associated with increased levels of certain LO products, a phenomenon known as aspirin‐sensiti...

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Veröffentlicht in:	British journal of pharmacology 2002-12, Vol.137 (7), p.1031-1038
Hauptverfasser:	Gray, P A, Warner, T D, Vojnovic, I, Del Soldato, P, Parikh, A, Scadding, G K, Mitchell, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin Aspirin - administration & dosage asthma Asthma - blood Asthma - chemically induced Asthma - enzymology Benzene Derivatives - pharmacology Biological and medical sciences Calcimycin - pharmacology COX‐1 COX‐2 Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology cyclo‐oxygenase Dinoprostone - blood Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Furans - pharmacology Humans Indomethacin - pharmacology Ionophores - pharmacology Isoenzymes - blood Isoenzymes - drug effects leukotrienes Leukotrienes - blood Lipopolysaccharides - pharmacology lipoxygenase Lipoxygenase - blood Lipoxygenase - drug effects Medical sciences Membrane Proteins NSAID Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - blood Prostaglandin-Endoperoxide Synthases - drug effects prostaglandins Sulfonamides - pharmacology Thromboxane B2 - blood Toxicity: respiratory system, ent, stomatology whole blood
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