Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines
The calcitonin receptor‐like receptor (CRLR) and specific receptor activity modifying proteins (RAMPs) together form receptors for calcitonin gene‐related peptide (CGRP) and/or adrenomedullin in transfected cells. There is less evidence that innate CGRP and adrenomedullin receptors are formed by CRL...
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| Veröffentlicht in: | British journal of pharmacology 2002-07, Vol.136 (5), p.784-792 |
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| creator | Choksi, Tejal Hay, Debbie L Legon, Stephen Poyner, David R Hagner, Stefanie Bloom, Stephen R Smith, David M |
| description | The calcitonin receptor‐like receptor (CRLR) and specific receptor activity modifying proteins (RAMPs) together form receptors for calcitonin gene‐related peptide (CGRP) and/or adrenomedullin in transfected cells.
There is less evidence that innate CGRP and adrenomedullin receptors are formed by CRLR/RAMP combinations. We therefore examined whether CGRP and/or adrenomedullin binding correlated with CRLR and RAMP mRNA expression in human and rat cell lines known to express these receptors. Specific human or rat CRLR antibodies were used to examine the presence of CRLR in these cells.
We confirmed CGRP subtype 1 receptor (CGRP1) pharmacology in SK‐N‐MC neuroblastoma cells. L6 myoblast cells expressed both CGRP1 and adrenomedullin receptors whereas Rat‐2 fibroblasts expressed only adrenomedullin receptors. In contrast we could not confirm CGRP2 receptor pharmacology for Col‐29 colonic epithelial cells, which, instead were CGRP1‐like in this study.
L6, SK‐N‐MC and Col‐29 cells expressed mRNA for RAMP1 and RAMP2 but Rat‐2 fibroblasts had only RAMP2. No cell line had detectable RAMP3 mRNA.
SK‐N‐MC, Col‐29 and Rat‐2 fibroblast cells expressed CRLR mRNA. By contrast, CRLR mRNA was undetectable by Northern analysis in one source of L6 cells. Conversely, a different source of L6 cells had mRNA for CRLR. All of the cell lines expressed CRLR protein. Thus, circumstances where CRLR mRNA is apparently absent by Northern analysis do not exclude the presence of this receptor.
These data strongly support CRLR, together with appropriate RAMPs as binding sites for CGRP and adrenomedullin in cultured cells.
British Journal of Pharmacology (2002) 136, 784–792; doi:10.1038/sj.bjp.0704761 |
| doi_str_mv | 10.1038/sj.bjp.0704761 |
| format | Article |
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There is less evidence that innate CGRP and adrenomedullin receptors are formed by CRLR/RAMP combinations. We therefore examined whether CGRP and/or adrenomedullin binding correlated with CRLR and RAMP mRNA expression in human and rat cell lines known to express these receptors. Specific human or rat CRLR antibodies were used to examine the presence of CRLR in these cells.
We confirmed CGRP subtype 1 receptor (CGRP1) pharmacology in SK‐N‐MC neuroblastoma cells. L6 myoblast cells expressed both CGRP1 and adrenomedullin receptors whereas Rat‐2 fibroblasts expressed only adrenomedullin receptors. In contrast we could not confirm CGRP2 receptor pharmacology for Col‐29 colonic epithelial cells, which, instead were CGRP1‐like in this study.
L6, SK‐N‐MC and Col‐29 cells expressed mRNA for RAMP1 and RAMP2 but Rat‐2 fibroblasts had only RAMP2. No cell line had detectable RAMP3 mRNA.
SK‐N‐MC, Col‐29 and Rat‐2 fibroblast cells expressed CRLR mRNA. By contrast, CRLR mRNA was undetectable by Northern analysis in one source of L6 cells. Conversely, a different source of L6 cells had mRNA for CRLR. All of the cell lines expressed CRLR protein. Thus, circumstances where CRLR mRNA is apparently absent by Northern analysis do not exclude the presence of this receptor.
These data strongly support CRLR, together with appropriate RAMPs as binding sites for CGRP and adrenomedullin in cultured cells.
British Journal of Pharmacology (2002) 136, 784–792; doi:10.1038/sj.bjp.0704761</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0704761</identifier><identifier>PMID: 12086988</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenomedullin ; Animals ; Calcitonin Gene-Related Peptide - metabolism ; Calcitonin Receptor-Like Protein ; Carrier Proteins - biosynthesis ; Cell Line ; CGRP ; Col‐29 cells ; CRLR ; DNA-Binding Proteins - biosynthesis ; Humans ; L6 myoblasts ; Peptides - metabolism ; Protein Binding - physiology ; RAMP ; Rats ; Rat‐2 fibroblasts ; Receptors, Adrenomedullin ; Receptors, Calcitonin - biosynthesis ; Receptors, Peptide - metabolism ; SK‐N‐MC neuroblastoma cells ; Transcription Factors</subject><ispartof>British journal of pharmacology, 2002-07, Vol.136 (5), p.784-792</ispartof><rights>2002 British Pharmacological Society</rights><rights>Copyright Nature Publishing Group Jul 2002</rights><rights>Copyright 2002, Nature Publishing Group 2002 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-e22b8f99aaca87ad22b85eb3d874b50ca626719de066077aed2404f1736233843</citedby><cites>FETCH-LOGICAL-c4574-e22b8f99aaca87ad22b85eb3d874b50ca626719de066077aed2404f1736233843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573393/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573393/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,1412,1428,27905,27906,45555,45556,46390,46814,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12086988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choksi, Tejal</creatorcontrib><creatorcontrib>Hay, Debbie L</creatorcontrib><creatorcontrib>Legon, Stephen</creatorcontrib><creatorcontrib>Poyner, David R</creatorcontrib><creatorcontrib>Hagner, Stefanie</creatorcontrib><creatorcontrib>Bloom, Stephen R</creatorcontrib><creatorcontrib>Smith, David M</creatorcontrib><title>Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>The calcitonin receptor‐like receptor (CRLR) and specific receptor activity modifying proteins (RAMPs) together form receptors for calcitonin gene‐related peptide (CGRP) and/or adrenomedullin in transfected cells.
There is less evidence that innate CGRP and adrenomedullin receptors are formed by CRLR/RAMP combinations. We therefore examined whether CGRP and/or adrenomedullin binding correlated with CRLR and RAMP mRNA expression in human and rat cell lines known to express these receptors. Specific human or rat CRLR antibodies were used to examine the presence of CRLR in these cells.
We confirmed CGRP subtype 1 receptor (CGRP1) pharmacology in SK‐N‐MC neuroblastoma cells. L6 myoblast cells expressed both CGRP1 and adrenomedullin receptors whereas Rat‐2 fibroblasts expressed only adrenomedullin receptors. In contrast we could not confirm CGRP2 receptor pharmacology for Col‐29 colonic epithelial cells, which, instead were CGRP1‐like in this study.
L6, SK‐N‐MC and Col‐29 cells expressed mRNA for RAMP1 and RAMP2 but Rat‐2 fibroblasts had only RAMP2. No cell line had detectable RAMP3 mRNA.
SK‐N‐MC, Col‐29 and Rat‐2 fibroblast cells expressed CRLR mRNA. By contrast, CRLR mRNA was undetectable by Northern analysis in one source of L6 cells. Conversely, a different source of L6 cells had mRNA for CRLR. All of the cell lines expressed CRLR protein. Thus, circumstances where CRLR mRNA is apparently absent by Northern analysis do not exclude the presence of this receptor.
These data strongly support CRLR, together with appropriate RAMPs as binding sites for CGRP and adrenomedullin in cultured cells.
British Journal of Pharmacology (2002) 136, 784–792; doi:10.1038/sj.bjp.0704761</description><subject>Adrenomedullin</subject><subject>Animals</subject><subject>Calcitonin Gene-Related Peptide - metabolism</subject><subject>Calcitonin Receptor-Like Protein</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Cell Line</subject><subject>CGRP</subject><subject>Col‐29 cells</subject><subject>CRLR</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>Humans</subject><subject>L6 myoblasts</subject><subject>Peptides - metabolism</subject><subject>Protein Binding - physiology</subject><subject>RAMP</subject><subject>Rats</subject><subject>Rat‐2 fibroblasts</subject><subject>Receptors, Adrenomedullin</subject><subject>Receptors, Calcitonin - biosynthesis</subject><subject>Receptors, Peptide - metabolism</subject><subject>SK‐N‐MC neuroblastoma cells</subject><subject>Transcription Factors</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFksFu1DAQhi0EokvhyhFZHFB7yGLHSexckEpUWqRFrFZwthxn0nXI2sFOWvbWR-BJeCieBC-7aoELp_HMfPPPjDwIPadkTgkTr0M3r7thTjjJeEEfoBmNNsmZoA_RjBDCE0qFOEJPQugIiUmeP0ZHNCWiKIWYoR-V2wzKm-Asdi0e14Dh2-AhBLOPaNVrMzprLPagYRid_3n7vTdf4M7HJ9VqsTrFyjb3MaVHc23GLd64xrRbY6_w4N0IxgZ8sjr7sAyn-MaMa1xdrJa_S1XjwboNNFPfx261sc2uKj419D2OMQhP0aNW9QGeHewx-vzu_FN1mSw-XryvzhaJznKeJZCmtWjLUimtBFfNzs2hZo3gWZ0TrYq04LRsgBQF4VxBk2YkaylnRcqYyNgxerPXHaY6TqTBjl71cvBmo_xWOmXk3xlr1vLKXUuac8ZKFgVeHQS8-zpBGOXGhN0eyoKbguRU5Hlaigi-_Afs3ORtXE6mNFKlICRC8z2kvQvBQ3s3CSVydwcydDLegTzcQSx48ef89_jh4yPA9sCN6WH7Hzn5dnmZ8TxjvwCk08Or</recordid><startdate>200207</startdate><enddate>200207</enddate><creator>Choksi, Tejal</creator><creator>Hay, Debbie L</creator><creator>Legon, Stephen</creator><creator>Poyner, David R</creator><creator>Hagner, Stefanie</creator><creator>Bloom, Stephen R</creator><creator>Smith, David M</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200207</creationdate><title>Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines</title><author>Choksi, Tejal ; Hay, Debbie L ; Legon, Stephen ; Poyner, David R ; Hagner, Stefanie ; Bloom, Stephen R ; Smith, David M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-e22b8f99aaca87ad22b85eb3d874b50ca626719de066077aed2404f1736233843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adrenomedullin</topic><topic>Animals</topic><topic>Calcitonin Gene-Related Peptide - metabolism</topic><topic>Calcitonin Receptor-Like Protein</topic><topic>Carrier Proteins - biosynthesis</topic><topic>Cell Line</topic><topic>CGRP</topic><topic>Col‐29 cells</topic><topic>CRLR</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>Humans</topic><topic>L6 myoblasts</topic><topic>Peptides - metabolism</topic><topic>Protein Binding - physiology</topic><topic>RAMP</topic><topic>Rats</topic><topic>Rat‐2 fibroblasts</topic><topic>Receptors, Adrenomedullin</topic><topic>Receptors, Calcitonin - biosynthesis</topic><topic>Receptors, Peptide - metabolism</topic><topic>SK‐N‐MC neuroblastoma cells</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choksi, Tejal</creatorcontrib><creatorcontrib>Hay, Debbie L</creatorcontrib><creatorcontrib>Legon, Stephen</creatorcontrib><creatorcontrib>Poyner, David R</creatorcontrib><creatorcontrib>Hagner, Stefanie</creatorcontrib><creatorcontrib>Bloom, Stephen R</creatorcontrib><creatorcontrib>Smith, David M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choksi, Tejal</au><au>Hay, Debbie L</au><au>Legon, Stephen</au><au>Poyner, David R</au><au>Hagner, Stefanie</au><au>Bloom, Stephen R</au><au>Smith, David M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2002-07</date><risdate>2002</risdate><volume>136</volume><issue>5</issue><spage>784</spage><epage>792</epage><pages>784-792</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>The calcitonin receptor‐like receptor (CRLR) and specific receptor activity modifying proteins (RAMPs) together form receptors for calcitonin gene‐related peptide (CGRP) and/or adrenomedullin in transfected cells.
There is less evidence that innate CGRP and adrenomedullin receptors are formed by CRLR/RAMP combinations. We therefore examined whether CGRP and/or adrenomedullin binding correlated with CRLR and RAMP mRNA expression in human and rat cell lines known to express these receptors. Specific human or rat CRLR antibodies were used to examine the presence of CRLR in these cells.
We confirmed CGRP subtype 1 receptor (CGRP1) pharmacology in SK‐N‐MC neuroblastoma cells. L6 myoblast cells expressed both CGRP1 and adrenomedullin receptors whereas Rat‐2 fibroblasts expressed only adrenomedullin receptors. In contrast we could not confirm CGRP2 receptor pharmacology for Col‐29 colonic epithelial cells, which, instead were CGRP1‐like in this study.
L6, SK‐N‐MC and Col‐29 cells expressed mRNA for RAMP1 and RAMP2 but Rat‐2 fibroblasts had only RAMP2. No cell line had detectable RAMP3 mRNA.
SK‐N‐MC, Col‐29 and Rat‐2 fibroblast cells expressed CRLR mRNA. By contrast, CRLR mRNA was undetectable by Northern analysis in one source of L6 cells. Conversely, a different source of L6 cells had mRNA for CRLR. All of the cell lines expressed CRLR protein. Thus, circumstances where CRLR mRNA is apparently absent by Northern analysis do not exclude the presence of this receptor.
These data strongly support CRLR, together with appropriate RAMPs as binding sites for CGRP and adrenomedullin in cultured cells.
British Journal of Pharmacology (2002) 136, 784–792; doi:10.1038/sj.bjp.0704761</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12086988</pmid><doi>10.1038/sj.bjp.0704761</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; PubMed Central; Alma/SFX Local Collection |
| subjects | Adrenomedullin Animals Calcitonin Gene-Related Peptide - metabolism Calcitonin Receptor-Like Protein Carrier Proteins - biosynthesis Cell Line CGRP Col‐29 cells CRLR DNA-Binding Proteins - biosynthesis Humans L6 myoblasts Peptides - metabolism Protein Binding - physiology RAMP Rats Rat‐2 fibroblasts Receptors, Adrenomedullin Receptors, Calcitonin - biosynthesis Receptors, Peptide - metabolism SK‐N‐MC neuroblastoma cells Transcription Factors |
| title | Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines |
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