KMUP‐1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K+ channels

In isolated endothelium‐intact or denuded rabbit corpus cavernosum preconstricted with phenylephrine, KMUP‐1 (0.001 – 10 μM) caused a concentration‐dependent relaxation. This relaxation of KMUP‐1 was attenuated by endothelium removed, high K+ and pretreatments with a soluble guanylyl cyclase (sGC) i...

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Veröffentlicht in:	British journal of pharmacology 2002-03, Vol.135 (5), p.1159-1166
Hauptverfasser:	Lin, Rong‐Jyh, Wu, Bin‐Nan, Lo, Yi‐Ching, Shen, Kuo‐Pyng, Lin, Young‐Tso, Huang, Chun‐Hsiung, Chen, Ing‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured corpus cavernosum Cyclic GMP Cyclic GMP - metabolism Enzyme Inhibitors - pharmacology Guanylate Cyclase - antagonists & inhibitors In Vitro Techniques intracavernous pressure K+ channels Male Medical sciences Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiology Nitric Oxide Synthase - antagonists & inhibitors Penile Erection - drug effects Penis - drug effects Penis - metabolism Penis - physiology Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - metabolism Piperazines - pharmacology Piperidines - pharmacology Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Purines Rabbits Sildenafil Citrate Sulfones Xanthines - pharmacology
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