Cyclosporin A‐induced free radical generation is not mediated by cytochrome P‐450

Reactive oxygen species (ROS) have been proposed to play a role in the side effects of the immunosuppressive drug cyclosporin A (CsA). The aim of this study was to investigate whether cytochrome P‐450 (CYP) dependent metabolism of CsA could be responsible for ROS generation since it has been suggest...

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Veröffentlicht in:	British journal of pharmacology 2002-02, Vol.135 (4), p.977-986
Hauptverfasser:	Krauskopf, Alexandra, Buetler, Timo M, Nguyen, Nathalie S D, Macé, Katherine, Ruegg, Urs T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Biological and medical sciences Cells, Cultured Cyclosporin A Cyclosporine - pharmacology Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P‐450 Drug toxicity and drugs side effects treatment Enzyme Inhibitors - pharmacology Epithelial Cells - enzymology Epithelial Cells - metabolism Free Radicals - metabolism Humans Immunosuppressive Agents - pharmacology In Vitro Techniques Male Medical sciences metabolism microsomes Microsomes, Liver - enzymology Microsomes, Liver - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - metabolism NADPH cytochrome P‐450 reductase Pharmacology. Drug treatments Rats Rats, Inbred WKY Rats, Sprague-Dawley reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - analysis smooth muscle cells Toxicity: digestive system
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