A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid haemorrhage in rats

Systemic administration of recombinant erythropoietin (EPO) has been demonstrated to mediate neuroprotection. This effect of EPO may in part rely on a beneficial effect on cerebrovascular dysfunction leading to ischaemic neuronal damage. We investigated the in vivo effects of subcutaneously administ...

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Veröffentlicht in:	British journal of pharmacology 2002-02, Vol.135 (3), p.823-829
Hauptverfasser:	Springborg, Jacob Bertram, Ma, XiaoDong, Rochat, Per, Knudsen, Gitte Moos, Amtorp, Ole, Paulson, Olaf B, Juhler, Marianne, Olsen, Niels Vidiendal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoregulation Biological and medical sciences Blood Pressure - drug effects Cardiovascular system cerebral blood flow Cerebrovascular Circulation - drug effects erythropoietin Erythropoietin - administration & dosage Homeostasis - drug effects Injections, Subcutaneous Male Medical sciences Miscellaneous Pharmacology. Drug treatments Rats Rats, Sprague-Dawley subarachnoid haemorrhage Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - physiopathology
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