The β‐lactam antibiotics, penicillin‐G and cefoselis have different mechanisms and sites of action at GABAA receptors

The action of the β‐lactam antibiotics, penicillin‐G (PCG) and cefoselis (CFSL) on GABAA receptors (GABAA‐R) was investigated using the two‐electrode voltage clamp technique and Xenopus oocyte expressed murine GABAA‐R. Murine GABAA‐Rs were expressed in Xenopus oocytes by injecting cRNA that encoded...

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Veröffentlicht in:	British journal of pharmacology 2002-01, Vol.135 (2), p.427-432
Hauptverfasser:	Sugimoto, Masahiro, Fukami, Sakae, Kayakiri, Hiroshi, Yamazaki, Shunji, Matsuoka, Nobuya, Uchida, Ichiro, Mashimo, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Biological and medical sciences convulsion Drug toxicity and drugs side effects treatment electrophysiology GABAA receptor Medical sciences mutation Pharmacology. Drug treatments picrotoxin Toxicity: nervous system and muscle Xenopus oocytes
Online-Zugang:	Volltext
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