Role of tachykinin NK receptors on the local and remote injuries following ischaemia and reperfusion of the superior mesenteric artery in the rat

Neuropeptides acting on tachykinin NK receptors play an important role in the amplification of inflammatory responses. We have assessed the effects of tachykinin NK receptor blockade on the injuries following intestinal ischaemia and reperfusion (I/R) in rats. The tachykinin NK1 receptor antagonist...

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Veröffentlicht in:	British journal of pharmacology 2002-01, Vol.135 (2), p.303-312
Hauptverfasser:	Souza, Danielle G, Mendonça, Vanessa A, Castro, Maria Salete de A, Poole, Steve, Teixeira, Mauro M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Capillary Permeability - drug effects Capillary Permeability - physiology Capsaicin Cardiovascular system Dose-Response Relationship, Drug IL‐10 Intestines - drug effects Intestines - physiopathology ischaemia and reperfusion injury Lung - drug effects Lung - physiopathology Male Medical sciences Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - physiopathology Miscellaneous Neutrophil Infiltration - drug effects Neutrophil Infiltration - physiology NK receptors Pharmacology. Drug treatments Piperidines - pharmacology Piperidines - therapeutic use Quinuclidines - pharmacology Quinuclidines - therapeutic use Rats Rats, Wistar Receptors, Tachykinin - antagonists & inhibitors Receptors, Tachykinin - physiology Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - physiopathology substance P tachykinins TNF‐α
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