Pharmacological profile of the novel mammalian tachykinin, hemokinin 1

The effects of the novel mammalian tachykinin, hemokinin 1 (HEK‐1), have been investigated by radioligand binding and functional in vitro and in vivo experiments. Similar to SP (Ki=0.13 nM), HEK‐1 inhibited in a concentration‐dependent manner and with high affinity [3H]‐substance P (SP) binding to h...

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Veröffentlicht in:	British journal of pharmacology 2002-01, Vol.135 (1), p.266-274
Hauptverfasser:	Bellucci, Francesca, Carini, Francesca, Catalani, Claudio, Cucchi, Paola, Lecci, Alessandro, Meini, Stefania, Patacchini, Riccardo, Quartara, Laura, Ricci, Renzo, Tramontana, Manuela, Giuliani, Sandro, Maggi, Carlo Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Binding, Competitive Biological and medical sciences Blood Pressure - drug effects Blood vessels and receptors cardiovascular effects CHO Cells Cricetinae Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Guinea Pigs Heart Heart Rate - drug effects Hemokinin 1 Ileum - drug effects Ileum - physiology Male Muscle, Smooth - drug effects Muscle, Smooth - physiology Protein Precursors - pharmacology Pulmonary Artery - drug effects Pulmonary Artery - physiology Rabbits Radioligand Assay Rats Rats, Wistar Receptors, Neurokinin-1 - agonists Receptors, Neurokinin-1 - metabolism Receptors, Neurokinin-2 - agonists Receptors, Neurokinin-2 - metabolism Receptors, Neurokinin-3 - agonists Receptors, Neurokinin-3 - metabolism Receptors, Tachykinin - agonists Receptors, Tachykinin - metabolism Saliva - metabolism salivary secretion Salivation - drug effects Salivation - physiology Sequence Homology, Amino Acid tachykinin NK1, NK2, NK3 receptors tachykinins Tachykinins - pharmacology Urinary Bladder - drug effects Urinary Bladder - physiology Vertebrates: cardiovascular system
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