Tissue‐specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice

The role of smooth muscle‐derived lipoprotein lipase (LPL) that translocates to the endothelium surface on vascular dysfunction during atherogenesis is unclear. Thus, the role of vascular LPL on blood vessel reactivity was assessed in transgenic mice that specifically express human LPL in the circul...

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Veröffentlicht in:	British journal of pharmacology 2002-01, Vol.135 (1), p.143-154
Hauptverfasser:	Esenabhalu, Victor E, Cerimagic, Mirza, Malli, Roland, Osibow, Karin, Levak‐Frank, Sanja, Frieden, Maud, Sattler, Wolfgang, Kostner, Gerhard M, Zechner, Rudolf, Graier, Wolfgang F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adenosine Triphosphate - pharmacology Adipose Tissue - metabolism Animals Aorta - metabolism Atherosclerosis Atherosclerosis (general aspects, experimental research) Autacoids - pharmacology Biological and medical sciences Blood and lymphatic vessels Blotting, Northern Calcium Signaling - drug effects Cardiology. Vascular system contraction Dose-Response Relationship, Drug endothelial Ca2 Endothelium, Vascular - physiology endothelium‐dependent relaxation Fatty Acids, Nonesterified - analysis free fatty acids Gene Expression Regulation Humans Lipoprotein Lipase - biosynthesis Lipoprotein Lipase - genetics Medical sciences Mice Mice, Transgenic Muscle, Smooth, Vascular - blood supply Muscle, Smooth, Vascular - metabolism Myocardium - metabolism NADH/NADPH oxidase Nitric Oxide - metabolism Nitroprusside - pharmacology Organ Specificity Phenylephrine - pharmacology Potassium Chloride - pharmacology protein kinase RNA, Messenger - genetics RNA, Messenger - metabolism superoxide anions Superoxides - metabolism Triglycerides - blood Vasoconstriction - drug effects Vasodilation - drug effects
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