Orexin A and B evoke noradrenaline release from rat cerebrocortical slices

Orexin A and B, recently identified in the rat hypothalamus are endogenous neuropeptide agonists for the G‐protein coupled orexin‐1 (OX1) and orexin‐2 (OX2) receptors. In the present study, we have examined the effects of orexin A, B and raised extracellular K+ on noradrenaline release from the rat...

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Veröffentlicht in:	British journal of pharmacology 2001-12, Vol.134 (7), p.1461-1466
Hauptverfasser:	Hirota, Kazuyoshi, Kushikata, Tetsuya, Kudo, Mihoko, Kudo, Tsuyoshi, Lambert, David G, Matsuki, Akitomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carrier Proteins - pharmacology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - drug effects Cerebral Cortex - metabolism Dopamine - secretion Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Glutamic Acid - secretion Histamine - metabolism In Vitro Techniques Intracellular Signaling Peptides and Proteins Male Neuropeptides - pharmacology noradrenaline Norepinephrine - secretion Orexin Orexins Potassium - pharmacology rat cerebrocortical slices Rats Rats, Wistar Serotonin - secretion Time Factors Vertebrates: nervous system and sense organs
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