Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain

Clinical studies have shown enhancement of cyclosporine toxicity when co‐administered with the immunosuppressant sirolimus. We evaluated the biochemical mechanisms underlying the sirolimus/cyclosporine interaction on rat brain metabolism using magnetic resonance spectroscopy (MRS) and compared the e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 2001-07, Vol.133 (6), p.875-885
Hauptverfasser:	Serkova, Natalie, Jacobsen, Wolfgang, Niemann, Claus U, Litt, Lawrence, Benet, Leslie Z, Leibfritz, Dieter, Christians, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - analogs & derivatives Aspartic Acid - drug effects Aspartic Acid - metabolism Biological and medical sciences Body Weight - drug effects Brain - drug effects Brain - metabolism Cyclosporine - blood Cyclosporine - pharmacology Cyclosporine toxicity Drug Synergism Drug toxicity and drugs side effects treatment Everolimus gamma-Aminobutyric Acid - drug effects gamma-Aminobutyric Acid - metabolism Glutamic Acid - drug effects Glutamic Acid - metabolism Glutamine - drug effects Glutamine - metabolism Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacology Magnetic Resonance Spectroscopy magnetic resonance spectroscopy (MRS) Medical sciences Mitochondria - drug effects Mitochondria - metabolism mitochondrial glucose metabolism Oxaloacetic Acid - metabolism oxidative phosphorylation pharmacodynamic drug interactions Pharmacology. Drug treatments Phosphates - metabolism Rats Rats, Wistar SDZ‐RAD sirolimus Sirolimus - analogs & derivatives Sirolimus - blood Sirolimus - pharmacology tissue distribution Toxicity: nervous system and muscle Weight Gain - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!