Effects of the endogenous opioid peptide, endomorphin 1, on supraoptic nucleus oxytocin and vasopressin neurones in vivo and in vitro

We investigated the actions of the endogenous opioid tetra‐peptide endomorphin 1, a selective μ‐opioid receptor agonist, on oxytocin and vasopressin cell activity in vivo and in vitro. The activity of antidromically‐identified supraoptic nucleus cells were recorded from urethane‐anaesthetized female...

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Veröffentlicht in:	British journal of pharmacology 2001-03, Vol.132 (5), p.1136-1144
Hauptverfasser:	Doi, Naomi, Brown, Colin H, Cohen, Helena Delgado, Leng, Gareth, Russell, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Analgesics, Opioid - pharmacology Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dependence Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation hypothalamus Hypothalamus. Hypophysis. Epiphysis. Urophysis magnocellular neurosecretory cell morphine naloxone Neurons - drug effects Neurons - physiology Oligopeptides - pharmacology Opioid Peptides - pharmacology Oxytocin - drug effects Oxytocin - physiology posterior pituitary Rats Rats, Sprague-Dawley supraoptic nucleus Supraoptic Nucleus - drug effects Supraoptic Nucleus - metabolism tolerance Vasopressins - drug effects Vasopressins - physiology Vertebrates: endocrinology Vertebrates: nervous system and sense organs μ‐opioid receptor
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