Ligand internalization and recycling by human recombinant somatostatin type 4 (h sst4) receptors expressed in CHO‐K1 cells

There is controversy as to whether somatostatin sst4 receptors internalize. In this study, CHO‐K1 cells expressing human sst4 receptor (CHOsst4 cells) cells internalized [125I]‐[11Tyr]‐SRIF in a time‐dependent manner, reaching a steady state at 60 min (1.4±0.1×104 molecules internalized per cell). I...

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Veröffentlicht in:	British journal of pharmacology 2001-03, Vol.132 (5), p.1102-1110
Hauptverfasser:	Smalley, K S M, Koenig, J A, Feniuk, W, Humphrey, P P A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - deficiency Animals Biological and medical sciences Cell receptors Cell structures and functions CHO Cells Cricetinae Endocytosis - drug effects Endocytosis - physiology Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans internalization Ligands Membrane Proteins Molecular and cellular biology receptor endocytosis Receptors, Somatostatin - drug effects Receptors, Somatostatin - metabolism Somatostatin (SRIF) Somatostatin - analogs & derivatives Somatostatin - metabolism Somatostatin - pharmacology sst2 receptors sst4 receptors Time Factors
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