Effects of (+)‐pentazocine and 1,3‐di‐o‐tolylguanidine (DTG), sigma (σ) ligands, on micturition in anaesthetized rats

The effects of two sigma (σ) binding site ligands, (+)‐pentazocine and 1,3‐di‐o‐tolylguanidine (DTG), on bladder functions were examined in rats. Cystometry using urethane‐anaesthetized rats showed that (+)‐pentazocine (1–5 mg kg−1, i.v.) and DTG (1–5 mg kg−1, i.v.) prolonged micturition intervals,...

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Veröffentlicht in:	British journal of pharmacology 2000-10, Vol.131 (3), p.610-616
Hauptverfasser:	Shimizu, Isao, Kawashima, Katsuyoshi, Ishii, Daisuke, Oka, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	(+)‐pentazocine Anesthesia Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Biological and medical sciences cystometry DTG Electric Stimulation Gi/o proteins Guanidines - pharmacology Ligands Male Medical sciences micturition Muscle Contraction - drug effects Narcotic Antagonists - pharmacology Narcotic Antagonists - therapeutic use Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pentazocine - pharmacology Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pertussis Toxin Pharmacology. Drug treatments Rats Rats, Wistar Receptors, sigma - metabolism Syncope - chemically induced Syncope - drug therapy Urinary Bladder - drug effects Urinary Bladder - metabolism Virulence Factors, Bordetella - pharmacology σ binding sites
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