Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner
Sphingolipids such as sphingosine‐1‐phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthetized rats. The animals were given intravenous or i...
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| creator | Bischoff, Angela Czyborra, Peter Meyer zu Heringdorf, Dagmar Jakobs, Karl H Michel, Martin C |
| description | Sphingolipids such as sphingosine‐1‐phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthetized rats.
The animals were given intravenous or intrarenal arterial bolus injections of sphingolipids (0.1–100 μg kg−1) with subsequent measurements of mean arterial pressure, heart rate and renal and mesenteric blood flows (RBF, MBF) using a pressure transducer and electromagnetic flow probes, respectively.
Intravenous injection of SPP rapidly (within 30 s), transiently and dose‐dependently reduced RBF (maximally −4.0±0.3 ml min−1) and MBF (maximally −1.4±0.2 ml min−1), without affecting mean arterial pressure or heart rate. Other sphingolipids had no significant effect.
Intrarenal arterial SPP administration caused greater blood flow reductions (maximally −6.4±0.3 ml min−1) than systemic administration. Upon intrarenal administration, sphingosylphos‐ phorylcholine also lowered RBF (maximally −2.8±0.6 ml min−1), while the other sphingolipids remained without effect.
Pretreatment with pertussis toxin (PTX, 10 μg kg−1) 3 days before the acute experiment abolished the SPP‐induced reductions of RBF and MBF.
These data demonstrate, that SPP is a potent vasoconstrictor in vivo, particularly in the renal vasculature, while the other structurally related sphingolipids had little if any effects. The PTX‐sensitivity strongly suggests that the effects of SPP on renal and mesenteric blood flow are mediated by receptors coupled to Gi‐type G‐proteins.
British Journal of Pharmacology (2000) 130, 1878–1883; doi:10.1038/sj.bjp.0703516 |
| doi_str_mv | 10.1038/sj.bjp.0703516 |
| format | Article |
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The animals were given intravenous or intrarenal arterial bolus injections of sphingolipids (0.1–100 μg kg−1) with subsequent measurements of mean arterial pressure, heart rate and renal and mesenteric blood flows (RBF, MBF) using a pressure transducer and electromagnetic flow probes, respectively.
Intravenous injection of SPP rapidly (within 30 s), transiently and dose‐dependently reduced RBF (maximally −4.0±0.3 ml min−1) and MBF (maximally −1.4±0.2 ml min−1), without affecting mean arterial pressure or heart rate. Other sphingolipids had no significant effect.
Intrarenal arterial SPP administration caused greater blood flow reductions (maximally −6.4±0.3 ml min−1) than systemic administration. Upon intrarenal administration, sphingosylphos‐ phorylcholine also lowered RBF (maximally −2.8±0.6 ml min−1), while the other sphingolipids remained without effect.
Pretreatment with pertussis toxin (PTX, 10 μg kg−1) 3 days before the acute experiment abolished the SPP‐induced reductions of RBF and MBF.
These data demonstrate, that SPP is a potent vasoconstrictor in vivo, particularly in the renal vasculature, while the other structurally related sphingolipids had little if any effects. The PTX‐sensitivity strongly suggests that the effects of SPP on renal and mesenteric blood flow are mediated by receptors coupled to Gi‐type G‐proteins.
British Journal of Pharmacology (2000) 130, 1878–1883; doi:10.1038/sj.bjp.0703516</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0703516</identifier><identifier>PMID: 10952678</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cell physiology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; kidney ; Kidney - blood supply ; Lysophospholipids ; Male ; Mesentery - blood supply ; Molecular and cellular biology ; Muscle contraction ; Pertussis Toxin ; Phosphorylcholine - analogs & derivatives ; Phosphorylcholine - pharmacology ; Psychosine - analogs & derivatives ; Psychosine - pharmacology ; rat ; Rats ; Rats, Wistar ; renal blood flow ; Renal Circulation - drug effects ; Sphingosine - analogs & derivatives ; Sphingosine - pharmacology ; Sphingosine‐1‐phosphate ; sphingosylphosphorylcholine ; Splanchnic Circulation - drug effects ; vasoconstriction ; Virulence Factors, Bordetella - pharmacology</subject><ispartof>British journal of pharmacology, 2000-08, Vol.130 (8), p.1878-1883</ispartof><rights>2000 British Pharmacological Society</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2000</rights><rights>Copyright 2000, Nature Publishing Group 2000 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5858-cf6b61a4bdee31f4e09eb568e677553621a04b8ac39ceffeb92510677feae5793</citedby><cites>FETCH-LOGICAL-c5858-cf6b61a4bdee31f4e09eb568e677553621a04b8ac39ceffeb92510677feae5793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572274/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572274/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1484063$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10952678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bischoff, Angela</creatorcontrib><creatorcontrib>Czyborra, Peter</creatorcontrib><creatorcontrib>Meyer zu Heringdorf, Dagmar</creatorcontrib><creatorcontrib>Jakobs, Karl H</creatorcontrib><creatorcontrib>Michel, Martin C</creatorcontrib><title>Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Sphingolipids such as sphingosine‐1‐phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthetized rats.
The animals were given intravenous or intrarenal arterial bolus injections of sphingolipids (0.1–100 μg kg−1) with subsequent measurements of mean arterial pressure, heart rate and renal and mesenteric blood flows (RBF, MBF) using a pressure transducer and electromagnetic flow probes, respectively.
Intravenous injection of SPP rapidly (within 30 s), transiently and dose‐dependently reduced RBF (maximally −4.0±0.3 ml min−1) and MBF (maximally −1.4±0.2 ml min−1), without affecting mean arterial pressure or heart rate. Other sphingolipids had no significant effect.
Intrarenal arterial SPP administration caused greater blood flow reductions (maximally −6.4±0.3 ml min−1) than systemic administration. Upon intrarenal administration, sphingosylphos‐ phorylcholine also lowered RBF (maximally −2.8±0.6 ml min−1), while the other sphingolipids remained without effect.
Pretreatment with pertussis toxin (PTX, 10 μg kg−1) 3 days before the acute experiment abolished the SPP‐induced reductions of RBF and MBF.
These data demonstrate, that SPP is a potent vasoconstrictor in vivo, particularly in the renal vasculature, while the other structurally related sphingolipids had little if any effects. The PTX‐sensitivity strongly suggests that the effects of SPP on renal and mesenteric blood flow are mediated by receptors coupled to Gi‐type G‐proteins.
British Journal of Pharmacology (2000) 130, 1878–1883; doi:10.1038/sj.bjp.0703516</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cell physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>kidney</subject><subject>Kidney - blood supply</subject><subject>Lysophospholipids</subject><subject>Male</subject><subject>Mesentery - blood supply</subject><subject>Molecular and cellular biology</subject><subject>Muscle contraction</subject><subject>Pertussis Toxin</subject><subject>Phosphorylcholine - analogs & derivatives</subject><subject>Phosphorylcholine - pharmacology</subject><subject>Psychosine - analogs & derivatives</subject><subject>Psychosine - pharmacology</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>renal blood flow</subject><subject>Renal Circulation - drug effects</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - pharmacology</subject><subject>Sphingosine‐1‐phosphate</subject><subject>sphingosylphosphorylcholine</subject><subject>Splanchnic Circulation - drug effects</subject><subject>vasoconstriction</subject><subject>Virulence Factors, Bordetella - pharmacology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUGL1DAUx4so7uzq1aMEEfHSMWmaNL0IuqgrLCio55CmrzspbVLz2hn3th_Bz-gnMcMMunrQQ3iB_-_9817-WfaI0TWjXL3Aft3005pWlAsm72QrVlYyF1yxu9mKUlrljCl1kp0i9pQmsRL3sxNGa1HISq2y3adp4_xVQOfhx813ls60CThtzAwkQrtYQBLNnO7eDMT4loyA4GeIzpJmCKEl3RB2xHmydduwr4ZMEOcF0SGZwzfnk2lqQTe7LZDReA_xQXavMwPCw2M9y768ffP5_CK__PDu_fmry9wKJVRuO9lIZsqmBeCsK4HW0AipQKZFBJcFM7RslLG8ttB10NSFYDSJHRgQVc3PspcH32lpRmhtmjyaQU_RjSZe62Cc_lPxbqOvwlYzURVFVSaDZ0eDGL4ugLMeHVoYBuMhLKgrVkkuSpXA5_8EGReyLqQs90M9-QvtwxLT_6Iu2N4whZOg9QGyMSBG6H4NzajeZ6-x1yl7fcw-NTy-veot_BB2Ap4eAYPWDF003jr8zZWqpJInjB-wnRvg-j-v6tcfL5ioFf8JVcHN3A</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Bischoff, Angela</creator><creator>Czyborra, Peter</creator><creator>Meyer zu Heringdorf, Dagmar</creator><creator>Jakobs, Karl H</creator><creator>Michel, Martin C</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200008</creationdate><title>Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner</title><author>Bischoff, Angela ; Czyborra, Peter ; Meyer zu Heringdorf, Dagmar ; Jakobs, Karl H ; Michel, Martin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5858-cf6b61a4bdee31f4e09eb568e677553621a04b8ac39ceffeb92510677feae5793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cell physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>kidney</topic><topic>Kidney - blood supply</topic><topic>Lysophospholipids</topic><topic>Male</topic><topic>Mesentery - blood supply</topic><topic>Molecular and cellular biology</topic><topic>Muscle contraction</topic><topic>Pertussis Toxin</topic><topic>Phosphorylcholine - analogs & derivatives</topic><topic>Phosphorylcholine - pharmacology</topic><topic>Psychosine - analogs & derivatives</topic><topic>Psychosine - pharmacology</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>renal blood flow</topic><topic>Renal Circulation - drug effects</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - pharmacology</topic><topic>Sphingosine‐1‐phosphate</topic><topic>sphingosylphosphorylcholine</topic><topic>Splanchnic Circulation - drug effects</topic><topic>vasoconstriction</topic><topic>Virulence Factors, Bordetella - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bischoff, Angela</creatorcontrib><creatorcontrib>Czyborra, Peter</creatorcontrib><creatorcontrib>Meyer zu Heringdorf, Dagmar</creatorcontrib><creatorcontrib>Jakobs, Karl H</creatorcontrib><creatorcontrib>Michel, Martin C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bischoff, Angela</au><au>Czyborra, Peter</au><au>Meyer zu Heringdorf, Dagmar</au><au>Jakobs, Karl H</au><au>Michel, Martin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2000-08</date><risdate>2000</risdate><volume>130</volume><issue>8</issue><spage>1878</spage><epage>1883</epage><pages>1878-1883</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>Sphingolipids such as sphingosine‐1‐phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthetized rats.
The animals were given intravenous or intrarenal arterial bolus injections of sphingolipids (0.1–100 μg kg−1) with subsequent measurements of mean arterial pressure, heart rate and renal and mesenteric blood flows (RBF, MBF) using a pressure transducer and electromagnetic flow probes, respectively.
Intravenous injection of SPP rapidly (within 30 s), transiently and dose‐dependently reduced RBF (maximally −4.0±0.3 ml min−1) and MBF (maximally −1.4±0.2 ml min−1), without affecting mean arterial pressure or heart rate. Other sphingolipids had no significant effect.
Intrarenal arterial SPP administration caused greater blood flow reductions (maximally −6.4±0.3 ml min−1) than systemic administration. Upon intrarenal administration, sphingosylphos‐ phorylcholine also lowered RBF (maximally −2.8±0.6 ml min−1), while the other sphingolipids remained without effect.
Pretreatment with pertussis toxin (PTX, 10 μg kg−1) 3 days before the acute experiment abolished the SPP‐induced reductions of RBF and MBF.
These data demonstrate, that SPP is a potent vasoconstrictor in vivo, particularly in the renal vasculature, while the other structurally related sphingolipids had little if any effects. The PTX‐sensitivity strongly suggests that the effects of SPP on renal and mesenteric blood flow are mediated by receptors coupled to Gi‐type G‐proteins.
British Journal of Pharmacology (2000) 130, 1878–1883; doi:10.1038/sj.bjp.0703516</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10952678</pmid><doi>10.1038/sj.bjp.0703516</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Cell physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Heart Rate - drug effects kidney Kidney - blood supply Lysophospholipids Male Mesentery - blood supply Molecular and cellular biology Muscle contraction Pertussis Toxin Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology Psychosine - analogs & derivatives Psychosine - pharmacology rat Rats Rats, Wistar renal blood flow Renal Circulation - drug effects Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine‐1‐phosphate sphingosylphosphorylcholine Splanchnic Circulation - drug effects vasoconstriction Virulence Factors, Bordetella - pharmacology |
| title | Sphingosine‐1‐phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin‐sensitive manner |
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