Mechanism of terfenadine block of ATP‐sensitive K+ channels

The ATP‐sensitive K+ (KATP) channel is a complex of a pore‐forming inwardly rectifying K+ channel (Kir6.2) and a sulphonylurea receptor (SUR). The aim of the present study was to gain further insight into the mechanism of block of KATP channels by terfenadine. Channel activity was recorded both from...

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Veröffentlicht in:	British journal of pharmacology 2000-08, Vol.130 (7), p.1571-1574
Hauptverfasser:	Zünkler, Bernd J, Kühne, Stephan, Rustenbeck, Ingo, Ott, Tilmann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters Biological and medical sciences Cercopithecus aethiops COS Cells Dose-Response Relationship, Drug Histamine and antagonists. Allergy Histamine H1 Antagonists - pharmacology KATP Channels Kir6.2 subunit Medical sciences Pharmacology. Drug treatments pH‐dependence pore‐forming Potassium Channel Blockers Potassium Channels - drug effects Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Rats Terfenadine Terfenadine - pharmacology Tumor Cells, Cultured
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