Potassium does not mimic EDHF in rat mesenteric arteries

K+ has been proposed to be EDHF in small arteries. We compared ACh‐stimulated, EDHF‐mediated dilatation/relaxation with raised [K+]o in rat mesenteric arteries. In pressurized arteries, ACh (10 μM) dilated all arteries. Raising [K+]o from 5.88 to 10.58 mM only dilated 30% of arteries. Ba2+ (30 μM) d...

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Veröffentlicht in:	British journal of pharmacology 2000-07, Vol.130 (5), p.1174-1182
Hauptverfasser:	Doughty, Joanne M, Boyle, John P, Langton, Philip D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals barium Barium - pharmacology Biological and medical sciences Biological Factors - physiology Blood vessels and receptors EDHF Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology gap junction Gap Junctions - physiology Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiology mesenteric artery ouabain Ouabain - pharmacology Potassium Potassium - physiology rat Rats Rats, Wistar Sodium-Potassium-Exchanging ATPase - physiology Vasodilation Vertebrates: cardiovascular system
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