Identification of the adenylyl cyclase‐activating 5‐hydroxytryptamine receptor subtypes expressed in the rat submandibular gland
Serotonin (5‐hydroxytryptamine, 5‐HT) has been shown to increase cyclic AMP production in dispersed cell aggregates from the major salivary glands of the rat. The goal of the present study was to identify the 5‐HT receptor subtypes that mediate these effects in rat submandibular glands (SMG). Among...
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| description | Serotonin (5‐hydroxytryptamine, 5‐HT) has been shown to increase cyclic AMP production in dispersed cell aggregates from the major salivary glands of the rat. The goal of the present study was to identify the 5‐HT receptor subtypes that mediate these effects in rat submandibular glands (SMG).
Among the 5‐HT receptor subtypes identified in the rat, 5‐HT4(a,b), 5‐HT6 and 5‐HT7(a,b,c) activate adenylyl cyclase (AC). We used subtype specific primers to screen rat SMG by reverse transcription‐PCR. Results indicate the presence of mRNA for 5‐HT4(b) and 5‐HT7(a) but not for 5‐HT4(a), 5‐HT6 and 5‐HT7(b,c).
In dispersed SMG cells, 5‐carboxyamidotryptamine (5‐CT), a 5‐HT7 receptor agonist, stimulated cyclic AMP synthesis with higher potency (EC50=27±5 nM) but lower efficacy than 5‐HT, suggesting a 5‐HT7 component and an additional component in the response to 5‐HT. The 5‐HT7 contribution was further supported by antagonism of the 5‐CT effect by metergoline, a 5‐HT7 antagonist, which exhibited an affinity (Ki=50 nM) similar to that obtained at the cloned 5‐HT7 receptor.
In the presence of a maximally effective concentration of 5‐CT, 5‐HT produced an additional increase in cyclic AMP production that was inhibited by the 5‐HT4 receptor antagonist, GR113808, suggesting that the second component of cyclic AMP production is mediated by 5‐HT4 receptors.
These findings indicate the presence in rat SMG of both 5‐HT4(b) and 5‐HT7(a) receptors positively coupled to AC.
British Journal of Pharmacology (2000) 130, 104–108; doi:10.1038/sj.bjp.0703303 |
| doi_str_mv | 10.1038/sj.bjp.0703303 |
| format | Article |
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Among the 5‐HT receptor subtypes identified in the rat, 5‐HT4(a,b), 5‐HT6 and 5‐HT7(a,b,c) activate adenylyl cyclase (AC). We used subtype specific primers to screen rat SMG by reverse transcription‐PCR. Results indicate the presence of mRNA for 5‐HT4(b) and 5‐HT7(a) but not for 5‐HT4(a), 5‐HT6 and 5‐HT7(b,c).
In dispersed SMG cells, 5‐carboxyamidotryptamine (5‐CT), a 5‐HT7 receptor agonist, stimulated cyclic AMP synthesis with higher potency (EC50=27±5 nM) but lower efficacy than 5‐HT, suggesting a 5‐HT7 component and an additional component in the response to 5‐HT. The 5‐HT7 contribution was further supported by antagonism of the 5‐CT effect by metergoline, a 5‐HT7 antagonist, which exhibited an affinity (Ki=50 nM) similar to that obtained at the cloned 5‐HT7 receptor.
In the presence of a maximally effective concentration of 5‐CT, 5‐HT produced an additional increase in cyclic AMP production that was inhibited by the 5‐HT4 receptor antagonist, GR113808, suggesting that the second component of cyclic AMP production is mediated by 5‐HT4 receptors.
These findings indicate the presence in rat SMG of both 5‐HT4(b) and 5‐HT7(a) receptors positively coupled to AC.
British Journal of Pharmacology (2000) 130, 104–108; doi:10.1038/sj.bjp.0703303</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1038/sj.bjp.0703303</identifier><identifier>PMID: 10781004</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>5‐hydroxytryptamine receptors ; Adenylyl cyclase ; Adenylyl Cyclases - drug effects ; Adenylyl Cyclases - metabolism ; Animals ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Cyclic AMP - metabolism ; Fundamental and applied biological sciences. Psychology ; Molecular and cellular biology ; Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) ; Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus ; Rats ; Receptors, Serotonin - drug effects ; Receptors, Serotonin - metabolism ; Receptors, Serotonin, 5-HT4 ; RNA, Messenger - drug effects ; RNA, Messenger - metabolism ; Serotonin - analogs & derivatives ; Serotonin - pharmacology ; Serotonin Antagonists - pharmacology ; Serotonin Receptor Agonists - pharmacology ; submandibular gland ; Submandibular Gland - drug effects ; Submandibular Gland - metabolism ; Vertebrates: digestive system</subject><ispartof>British journal of pharmacology, 2000-05, Vol.130 (1), p.104-108</ispartof><rights>2000 Nature Publishing Group</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2000</rights><rights>Copyright 2000, Nature Publishing Group 2000 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4863-29f682485e67964ea01670751cceb7c8fdd3d9efbedb28bb74346bec8ad57b173</citedby><cites>FETCH-LOGICAL-c4863-29f682485e67964ea01670751cceb7c8fdd3d9efbedb28bb74346bec8ad57b173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572050/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572050/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,1434,27929,27930,45579,45580,46414,46838,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1358020$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10781004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bourdon, D M</creatorcontrib><creatorcontrib>Camden, J M</creatorcontrib><creatorcontrib>Landon, L A</creatorcontrib><creatorcontrib>Levy, F O</creatorcontrib><creatorcontrib>Turner, J T</creatorcontrib><title>Identification of the adenylyl cyclase‐activating 5‐hydroxytryptamine receptor subtypes expressed in the rat submandibular gland</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Serotonin (5‐hydroxytryptamine, 5‐HT) has been shown to increase cyclic AMP production in dispersed cell aggregates from the major salivary glands of the rat. The goal of the present study was to identify the 5‐HT receptor subtypes that mediate these effects in rat submandibular glands (SMG).
Among the 5‐HT receptor subtypes identified in the rat, 5‐HT4(a,b), 5‐HT6 and 5‐HT7(a,b,c) activate adenylyl cyclase (AC). We used subtype specific primers to screen rat SMG by reverse transcription‐PCR. Results indicate the presence of mRNA for 5‐HT4(b) and 5‐HT7(a) but not for 5‐HT4(a), 5‐HT6 and 5‐HT7(b,c).
In dispersed SMG cells, 5‐carboxyamidotryptamine (5‐CT), a 5‐HT7 receptor agonist, stimulated cyclic AMP synthesis with higher potency (EC50=27±5 nM) but lower efficacy than 5‐HT, suggesting a 5‐HT7 component and an additional component in the response to 5‐HT. The 5‐HT7 contribution was further supported by antagonism of the 5‐CT effect by metergoline, a 5‐HT7 antagonist, which exhibited an affinity (Ki=50 nM) similar to that obtained at the cloned 5‐HT7 receptor.
In the presence of a maximally effective concentration of 5‐CT, 5‐HT produced an additional increase in cyclic AMP production that was inhibited by the 5‐HT4 receptor antagonist, GR113808, suggesting that the second component of cyclic AMP production is mediated by 5‐HT4 receptors.
These findings indicate the presence in rat SMG of both 5‐HT4(b) and 5‐HT7(a) receptors positively coupled to AC.
British Journal of Pharmacology (2000) 130, 104–108; doi:10.1038/sj.bjp.0703303</description><subject>5‐hydroxytryptamine receptors</subject><subject>Adenylyl cyclase</subject><subject>Adenylyl Cyclases - drug effects</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cyclic AMP - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Molecular and cellular biology</subject><subject>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</subject><subject>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</subject><subject>Rats</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Receptors, Serotonin, 5-HT4</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Serotonin - analogs & derivatives</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>submandibular gland</subject><subject>Submandibular Gland - drug effects</subject><subject>Submandibular Gland - metabolism</subject><subject>Vertebrates: digestive system</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc1u1DAUhS0EokNhyxJZCLHLYMdJ7NkglQpopUqwgLXln5sZjzxxsJ3S7FjwADwjT4KnM4LChpV_7ufjc3QQekrJkhImXqXtUm_HJeGEMcLuoQVteFe1TND7aEEI4RWlQpygRyltCSlD3j5EJ5RwQQlpFuj7pYUhu94ZlV0YcOhx3gBW5Xb2s8dmNl4l-PnthzLZXRdoWOO2HDezjeFmznEes9q5AXAEA2MOEadJ53mEhOFmjJASWOyGW9mo8n66U4N1evIq4rUv-8foQa98gifH9RR9fvf20_lFdfXh_eX52VVlGtGxql71nagb0ULHV10DitCOE95SY0BzI3prmV1Br8HqWmjNG9Z0GoxQtuWacnaKXh90x-IBrCnJo_JyjG6n4iyDcvLvyeA2ch2uJW15TVpSBF4eBWL4MkHKcueSAV9CQJiS5JR0nN2Cz_8Bt2GKQwkna8op543Y21keIBNDShH6304okft2ZdrK0q48tlsePLvr_w5-qLMAL46ASkb5PqrBuPSHY60g9d4dO2BfnYf5P7_KNx8vKOOM_QKPlsTO</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Bourdon, D M</creator><creator>Camden, J M</creator><creator>Landon, L A</creator><creator>Levy, F O</creator><creator>Turner, J T</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200005</creationdate><title>Identification of the adenylyl cyclase‐activating 5‐hydroxytryptamine receptor subtypes expressed in the rat submandibular gland</title><author>Bourdon, D M ; Camden, J M ; Landon, L A ; Levy, F O ; Turner, J T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4863-29f682485e67964ea01670751cceb7c8fdd3d9efbedb28bb74346bec8ad57b173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>5‐hydroxytryptamine receptors</topic><topic>Adenylyl cyclase</topic><topic>Adenylyl Cyclases - drug effects</topic><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cyclic AMP - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Molecular and cellular biology</topic><topic>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</topic><topic>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</topic><topic>Rats</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Receptors, Serotonin, 5-HT4</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Serotonin - analogs & derivatives</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>submandibular gland</topic><topic>Submandibular Gland - drug effects</topic><topic>Submandibular Gland - metabolism</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bourdon, D M</creatorcontrib><creatorcontrib>Camden, J M</creatorcontrib><creatorcontrib>Landon, L A</creatorcontrib><creatorcontrib>Levy, F O</creatorcontrib><creatorcontrib>Turner, J T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bourdon, D M</au><au>Camden, J M</au><au>Landon, L A</au><au>Levy, F O</au><au>Turner, J T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of the adenylyl cyclase‐activating 5‐hydroxytryptamine receptor subtypes expressed in the rat submandibular gland</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2000-05</date><risdate>2000</risdate><volume>130</volume><issue>1</issue><spage>104</spage><epage>108</epage><pages>104-108</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>Serotonin (5‐hydroxytryptamine, 5‐HT) has been shown to increase cyclic AMP production in dispersed cell aggregates from the major salivary glands of the rat. The goal of the present study was to identify the 5‐HT receptor subtypes that mediate these effects in rat submandibular glands (SMG).
Among the 5‐HT receptor subtypes identified in the rat, 5‐HT4(a,b), 5‐HT6 and 5‐HT7(a,b,c) activate adenylyl cyclase (AC). We used subtype specific primers to screen rat SMG by reverse transcription‐PCR. Results indicate the presence of mRNA for 5‐HT4(b) and 5‐HT7(a) but not for 5‐HT4(a), 5‐HT6 and 5‐HT7(b,c).
In dispersed SMG cells, 5‐carboxyamidotryptamine (5‐CT), a 5‐HT7 receptor agonist, stimulated cyclic AMP synthesis with higher potency (EC50=27±5 nM) but lower efficacy than 5‐HT, suggesting a 5‐HT7 component and an additional component in the response to 5‐HT. The 5‐HT7 contribution was further supported by antagonism of the 5‐CT effect by metergoline, a 5‐HT7 antagonist, which exhibited an affinity (Ki=50 nM) similar to that obtained at the cloned 5‐HT7 receptor.
In the presence of a maximally effective concentration of 5‐CT, 5‐HT produced an additional increase in cyclic AMP production that was inhibited by the 5‐HT4 receptor antagonist, GR113808, suggesting that the second component of cyclic AMP production is mediated by 5‐HT4 receptors.
These findings indicate the presence in rat SMG of both 5‐HT4(b) and 5‐HT7(a) receptors positively coupled to AC.
British Journal of Pharmacology (2000) 130, 104–108; doi:10.1038/sj.bjp.0703303</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10781004</pmid><doi>10.1038/sj.bjp.0703303</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 5‐hydroxytryptamine receptors Adenylyl cyclase Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Animals Biological and medical sciences Cell receptors Cell structures and functions Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Rats Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT4 RNA, Messenger - drug effects RNA, Messenger - metabolism Serotonin - analogs & derivatives Serotonin - pharmacology Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology submandibular gland Submandibular Gland - drug effects Submandibular Gland - metabolism Vertebrates: digestive system |
| title | Identification of the adenylyl cyclase‐activating 5‐hydroxytryptamine receptor subtypes expressed in the rat submandibular gland |
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