Role of uptake inhibition and autoreceptor activation in the control of 5‐HT release in the frontal cortex and dorsal hippocampus of the rat

Using brain microdialysis, we compared the relative role of 5‐hydroxytryptamine (5‐HT; serotonin) blockade and somatodendritic 5‐HT1A and/or terminal 5‐HT1B autoreceptor activation in the control of 5‐HT output. Fluoxetine (10 mg kg−1 i.p.) doubled the 5‐HT output in frontal cortex and dorsal hippoc...

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Veröffentlicht in:	British journal of pharmacology 2000-05, Vol.130 (1), p.160-166
Hauptverfasser:	Hervás, Ildefonso, Queiroz, Claudio M T, Adell, Albert, Artigas, Francesc
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT uptake 5‐HT1A receptors 5‐HT1B receptors 5‐Hydroxytryptamine Animals antidepressants Autoreceptors - drug effects Autoreceptors - metabolism Biological and medical sciences citalopram fluoxetine Fluoxetine - pharmacology frontal cortex Frontal Lobe - drug effects Frontal Lobe - metabolism hippocampus Hippocampus - drug effects Hippocampus - metabolism Male Medical sciences microdialysis Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Receptor, Serotonin, 5-HT1B Receptors, Serotonin - drug effects Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT1 Selective Serotonin Reuptake Inhibitors - pharmacology Serotonin - metabolism Serotoninergic system
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