O‐1057, a potent water‐soluble cannabinoid receptor agonist with antinociceptive properties

Cannabinoids have low water solubility, necessitating the use of a solubilizing agent. In this paper we investigated whether a novel water‐soluble cannabinoid, 3‐(5′‐cyano‐1′,1′‐dimethylpentyl)‐1‐(4‐N‐morpholinobutyryloxy)‐Δ8‐tetrahydrocannabinol hydrochloride (O‐1057), would interact with cannabino...

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Veröffentlicht in:	British journal of pharmacology 2000-04, Vol.129 (8), p.1577-1584
Hauptverfasser:	Pertwee, Roger G, Gibson, T Michael, Stevenson, Lesley A, Ross, Ruth A, Banner, W Kenneth, Saha, Bijali, Razdan, Raj K, Martin, Billy R
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐(5′‐cyano‐1′,1′‐dimethylpentyl)‐1‐(4‐N‐morpholinobutyryloxy)‐Δ8‐tetrahydrocannabinol hydrochloride Analgesics Analgesics - metabolism Analgesics - pharmacology Analgesics, Non-Narcotic - pharmacology Animals Binding, Competitive Biological and medical sciences body temperature cannabinoid CB1 receptors cannabinoid CB2 receptors Cannabinoids Cannabinoids - metabolism Cannabinoids - pharmacology CHO Cells Colforsin - pharmacology Cricetinae Cyclic AMP - metabolism Cyclohexanols - pharmacology Dronabinol - pharmacology Drug Interactions Guinea Pigs Male Medical sciences Mice Mice, Inbred ICR mouse tail flick test mouse vas deferens Muscle Contraction - drug effects Neuropharmacology O‐1057 Pharmacology. Drug treatments Rats Receptor, Cannabinoid, CB2 Receptors, Cannabinoid Receptors, Drug - agonists Solubility spontaneous activity Tritium Vas Deferens - drug effects Vas Deferens - physiology Water - chemistry
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